ANKRD15 antibody (AA 900-1000)

Catalog No. ABIN7265613

Product Details anti-ANKRD15 Antibody

Target: ANKRD15 (Ankyrin Repeat Domain 15 (ANKRD15))

Binding Specificity: AA 900-1000

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ANKRD15 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF)

Purpose: KANK1 Rabbit pAb

Sequence: GNYLGYTCKC GGLQSGSPLS SQTSQPEQEV GTSEGKPISS LDAFPTQEGT LSPVNLTDDQ IAAGLYACTN NESTLKSIMK KKDGNKDSNG AKKNLQFVGI N

Cross-Reactivity: Human, Mouse

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: A synthetic peptide corresponding to a sequence within amino acids 900-1000 of human KANK1 (NP_055973.2).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IF,1:50 - 1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for ANKRD15

Target: ANKRD15 (Ankyrin Repeat Domain 15 (ANKRD15))

Alternative Name: KANK1 (ANKRD15 Products)

Synonyms: ANKRD15 antibody, CPSQ2 antibody, KANK antibody, A930031B09Rik antibody, AU015049 antibody, AW121052 antibody, Ankrd15 antibody, D330024H06Rik antibody, mKIAA0172 antibody, KANK1 antibody, ankrd15 antibody, kank1.2 antibody, DMRT1 antibody, KN motif and ankyrin repeat domains 1 antibody, KN motif and ankyrin repeat domains 1 L homeolog antibody, doublesex and mab-3 related transcription factor 1 antibody, KANK1 antibody, Kank1 antibody, kank1.L antibody, DMRT1 antibody

Background: The protein encoded by this gene belongs to the Kank family of proteins, which contain multiple ankyrin repeat domains. This family member functions in cytoskeleton formation by regulating actin polymerization. This gene is a candidate tumor suppressor for renal cell carcinoma. Mutations in this gene cause cerebral palsy spastic quadriplegic type 2, a central nervous system development disorder. A t(5,9) translocation results in fusion of the platelet-derived growth factor receptor beta gene (PDGFRB) on chromosome 5 with this gene in a myeloproliferative neoplasm featuring severe thrombocythemia. Alternative splicing of this gene results in multiple transcript variants. A related pseudogene has been identified on chromosome 20.,KANK1,ANKRD15,CPSQ2,KANK,Cancer,Tumor suppressors,Signal Transduction,Cell Biology & Developmental Biology,Cytoskeleton,Microfilaments,KANK1

Molecular Weight: 129kDa/147kDa

Gene ID: 23189

UniProt: Q14678

Pathways: Regulation of Actin Filament Polymerization