arl2bp antibody, MGC81575 antibody, MGC84796 antibody, MGC130948 antibody, MGC107872 antibody, ARL2BP antibody, BART antibody, BART1 antibody, 1700010P10Rik antibody, 1700027H16Rik antibody, 6330544B05Rik antibody, AI482273 antibody, AI849834 antibody, Bart1 antibody, zgc:66308 antibody, zgc:77496 antibody, ADP ribosylation factor like GTPase 2 binding protein L homeolog antibody, ADP ribosylation factor like GTPase 2 binding protein antibody, ADP-ribosylation factor-like 2 binding protein antibody, ADP-ribosylation factor like GTPase 2 binding protein antibody, arl2bp.L antibody, arl2bp antibody, ARL2BP antibody, Arl2bp antibody
Background
ADP-ribosylation factor (ARF)-like proteins (ARLs) comprise a functionally distinct group of the ARF family of RAS-related GTPases. The protein encoded by this gene binds to ARL2.GTP with high affinity but does not interact with ARL2.GDP, activated ARF, or RHO proteins. The lack of detectable membrane association of this protein or ARL2 upon activation of ARL2 is suggestive of actions distinct from those of the ARFs. This protein is considered to be the first ARL2-specific effector identified, due to its interaction with ARL2.GTP but lack of ARL2 GTPase-activating protein activity.,ARL2BP,BART,BART1,RP66,Signal Transduction,G protein signaling,Signal Transduction,Cell Biology & Developmental Biology,Cell Cycle,Centrosome,ARL2BP