The protein encoded by this gene belongs to a distinct class of adenylyl cyclases that is soluble and insensitive to G protein or forskolin regulation. Activity of this protein is regulated by bicarbonate. Variation at this gene has been observed in patients with absorptive hypercalciuria. Alternatively spliced transcript variants encoding different isoforms have been observed. There is a pseudogene of this gene on chromosome 6. [provided by RefSeq, Jul 2014],HCA2,HEL-S-7a,SAC,SACI,Sacy,hsAC,ADCY10,Cancer,Endocrine & Metabolism,G protein signaling,G protein signaling_G-Protein-Coupled Receptors Signaling to MAPK/Erk,Neurodegenerative Diseases,Neurodegenerative Diseases_Dopamine Signaling in Parkinsons Disease,Neuroscience,Signal Transduction,ADCY10