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MEK1/2 antibody

MAP2K1/2 Reactivity: Human, Mouse, Rat, Monkey WB, ELISA, IHC (p), IF Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN7206521
  • Target See all MEK1/2 (MAP2K1/2) products
    MEK1/2 (MAP2K1/2) (Mitogen-Activated Protein Kinase Kinase 1/2 (MAP2K1/2))
    Reactivity
    • 78
    • 73
    • 73
    • 11
    • 4
    • 3
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    Human, Mouse, Rat, Monkey
    Host
    • 77
    • 1
    Rabbit
    Clonality
    • 69
    • 9
    Polyclonal
    Conjugate
    • 23
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    This MEK1/2 antibody is un-conjugated
    Application
    • 65
    • 27
    • 27
    • 20
    • 13
    • 6
    • 5
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)
    Purpose
    MEK-1/2 Polyclonal Antibody
    Specificity
    MEK-1/2 Polyclonal Antibody detects endogenous levels of MEK-1/2 protein.
    Purification
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
    Immunogen
    Synthesized peptide derived from human MEK-1/2 around the non-phosphorylation site of S218/222
    Isotype
    IgG
  • Application Notes
    Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), IF (1:50-1:200), IHC-P (1:50-1:300), ELISA (1:10000-1:20000). Not yet tested in other applications.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    PBS containing 50 % Glycerol, 0.5 % BSA and 0.02 % Sodium Azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
  • Target
    MEK1/2 (MAP2K1/2) (Mitogen-Activated Protein Kinase Kinase 1/2 (MAP2K1/2))
    Alternative Name
    MEK-1/2 (MAP2K1/2 Products)
    Background
    Rabbit Anti-MEK-1/2 Polyclonal Antibody,MAP2K1, MEK1, PRKMK1, Dual specificity mitogen-activated protein kinase kinase 1, MAP kinase kinase 1, MAPKK 1, MKK1, ERK activator kinase 1, MAPK/ERK kinase 1, MEK 1, MAP2K2, MEK2, MKK2, PRKMK2, Dual specificity mitogen-activated protein k,Dual specificity mitogen-activated protein kinase kinase 2 encoded by MAP2K2 is a dual specificity protein kinase that belongs to the MAP kinase kinase family. Dual specificity mitogen-activated protein kinase kinase 2 is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases. Mutations in this gene cause cardiofaciocutaneous syndrome (CFC syndrome), a disease characterized by heart defects, mental retardation, and distinctive facial features similar to those found in Noonan syndrome. The inhibition or degradation of this kinase is also found to be involved in the pathogenesis of Yersinia and anthrax. A pseudogene, which is located on chromosome 7, has been identified for this gene.,Dual specificity mitogen-activated protein kinase kinase 1
    Gene ID
    5604, 5605
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