DCAF6 antibody (AA 245-350)

Catalog No. ABIN715781

Product Details anti-DCAF6 Antibody

Target: DCAF6 (DDB1 and CUL4 Associated Factor 6 (DCAF6))

Binding Specificity: AA 245-350

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DCAF6 antibody is un-conjugated

Application: ELISA, Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Predicted Reactivity: Human,Mouse,Rat,Dog,Cow,Pig,Horse,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human NRIP

Isotype: IgG

Application Details

Application Notes: ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for DCAF6

Target: DCAF6 (DDB1 and CUL4 Associated Factor 6 (DCAF6))

Alternative Name: Nrip (DCAF6 Products)

Synonyms: 1200006M05Rik antibody, ARCAP antibody, IQWD1 antibody, MSTP055 antibody, NRIP antibody, PC326 antibody, Iqwd1 antibody, RGD1561961 antibody, DCAF6 antibody, si:rp71-20i5.1 antibody, arcap antibody, dcaf6 antibody, iqwd1 antibody, mstp055 antibody, nrip antibody, pc326 antibody, DDB1 and CUL4 associated factor 6 antibody, ddb1 and cul4 associated factor 6 antibody, DDB1 and CUL4 associated factor 6 S homeolog antibody, DCAF6 antibody, Dcaf6 antibody, dcaf6 antibody, dcaf6.S antibody

Background:

Synonyms: Androgen receptor complex associated protein, ARCAP, IQ mot and WD repeats 1, IQWD1v MSTP055, Nuclear receptor interaction protein, RP4 745I14.1, DCAF6_HUMAN.

Background: WD-repeat proteins are a large family of eukaryotic proteins coordinating multi-protein complex assemblies. Their role has been implicated in multiple cellular processes including signal transduction, transcriptional regulation, cell cycle control and apoptosis. NRIP is a novel 860a.a nuclear protein consisting of seven conserved WD40 domains and one NLS motif. It binds to androgen and glucocorticoid receptors and up-regulates their transcriptional activity, thereby functioning as a nuclear receptor co-activator. Role of NRIP has been implicated in cell growth and also in cervical and prostrate cancer, thus indicating a potential therapeutic intervention. Northern Blot analysis detects a high expression of NRIP in skeletal muscle and testis and low expression in heart, prostrate and adrenal gland.

Gene ID: 8204