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Recombinant TNF alpha (Infliximab Biosimilar) antibody

Reactivity: Human FACS, in vivo Host: Mouse Monoclonal cA2 unconjugated Recombinant Antibody
Catalog No. ABIN7200661
  • Target See all TNF alpha (Infliximab Biosimilar) products
    TNF alpha (Infliximab Biosimilar)
    Antibody Type
    Recombinant Antibody
    Reactivity
    Human
    Host
    • 1
    • 1
    • 1
    Mouse
    Clonality
    • 3
    Monoclonal
    Conjugate
    • 3
    This TNF alpha (Infliximab Biosimilar) antibody is un-conjugated
    Application
    • 3
    • 2
    • 2
    • 1
    Flow Cytometry (FACS), In vivo Studies (in vivo)
    Purpose
    Infliximab Biosimilar, TNF alpha Monoclonal Antibody
    Specificity
    The monoclonal antibody Infliximab biosimilar specifically binds to the human TNF alpha.
    Characteristics
    Recombinant Chimeric IgG1 Monoclonal Antibody.
    Purification
    Protein A affinity column
    Purity
    > 95% by SDS-PAGE under reducing conditions and HPLC.
    Sterility
    0.2 μm filtered
    Endotoxin Level
    < 1 EU per 1 mg of the protein by the LAL method.
    Immunogen
    The monoclonal antibody Infliximab biosimilar was produced in the Infliximab biosimilar CHO stable cell line.
    Clone
    CA2
    Isotype
    IgG1 kappa
  • Application Notes
    ELISA, neutralization, functional assays such as bioanalytical PK and ADA assays, and those assays for studying biological pathways affected by Infliximab.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    PBS, pH 7.4, no stabilizers or preservatives.
    Preservative
    Without preservative
    Handling Advice
    Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
    Storage
    -20 °C
    Storage Comment
    12 months from date of receipt, -20 to -70°C as supplied. 1 month from date of receipt, 2 to 8°C as supplied.
    Expiry Date
    12 months
  • Target
    TNF alpha (Infliximab Biosimilar)
    Abstract
    TNF alpha (Infliximab Biosimilar) Products
    Synonyms
    DIF antibody, TNF-alpha antibody, TNFA antibody, TNFSF2 antibody, tumor necrosis factor antibody, TNF antibody
    Target Type
    Biosimilar
    Background
    Infliximab, a chimeric anti-TNF-α monoclonal antibody, is used to treat psoriasis, Crohn's disease, ankylosing spondylitis, psoriatic arthritis, rheumatoid arthritis, and ulcerative colitis. Infliximab interferes TNF-α from binding to its receptor in the cell.

    Mainly produced by activated macrophages (M1), Tumor necrosis factor (TNF, cachexin, cachectin, tumor necrosis factor alpha, TNFα) plays important roles in the regulation of autoimmune reaction.
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