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Recombinant ErbB2/Her2 (Trastuzumab Biosimilar) antibody

Reactivity: Human FACS, in vivo Host: Mouse Monoclonal 4D5-8 unconjugated Recombinant Antibody
Catalog No. ABIN7200659
  • Target See all ErbB2/Her2 (Trastuzumab Biosimilar) products
    ErbB2/Her2 (Trastuzumab Biosimilar)
    Antibody Type
    Recombinant Antibody
    Reactivity
    Human
    Host
    • 1
    • 1
    • 1
    • 1
    Mouse
    Clonality
    • 4
    Monoclonal
    Conjugate
    • 4
    This ErbB2/Her2 (Trastuzumab Biosimilar) antibody is un-conjugated
    Application
    • 3
    • 3
    • 2
    Flow Cytometry (FACS), In vivo Studies (in vivo)
    Purpose
    Trastuzumab Biosimilar, HER2 Monoclonal Antibody
    Specificity
    The monoclonal antibody trastuzumab biosimilar specifically binds to the human HER2 / ErbB-2 / c-neu.
    Characteristics
    Recombinant Humanized IgG1 Monoclonal Antibody.
    Purification
    Protein A affinity column
    Purity
    > 95% by SDS-PAGE under reducing conditions and HPLC.
    Sterility
    0.2 μm filtered
    Endotoxin Level
    < 1 EU per 1 mg of the protein by the LAL method.
    Immunogen
    The monoclonal antibody trastuzumab biosimilar was produced in the trastuzumab biosimilar CHO stable cell line.
    Clone
    4D5-8
    Isotype
    IgG1 kappa
  • Application Notes
    ELISA, neutralization, functional assays such as bioanalytical PK and ADA assays, and those assays for studying biological pathways affected by trastuzumab.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    21.2 mg/mL
    Buffer
    PBS, pH 7.4, no stabilizers or preservatives.
    Preservative
    Without preservative
    Handling Advice
    Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
    Storage
    -20 °C
    Storage Comment
    12 months from date of receipt, -20 to -70°C as supplied. 1 month from date of receipt, 2 to 8°C as supplied.
    Expiry Date
    12 months
  • Target
    ErbB2/Her2 (Trastuzumab Biosimilar)
    Abstract
    ErbB2/Her2 (Trastuzumab Biosimilar) Products
    Synonyms
    CD340 antibody, HER-2 antibody, HER-2/neu antibody, HER2 antibody, MLN 19 antibody, NEU antibody, NGL antibody, TKR1 antibody, erb-b2 receptor tyrosine kinase 2 antibody, ERBB2 antibody
    Target Type
    Biosimilar
    Background
    Trastuzumab, a humanized monoclonal antibody, interferes with the HER2/neu receptor and is mainly used to treat certain breast cancers, especially HER2-positive metastatic breast cancer. Combined with chemotherapy, trastuzumab increases both survival and response rate.

    There are four closely related receptor tyrosine kinases in the ErbB family of receptors: EGFR (ErbB-1; HER1 in humans), HER2/c-neu (ErbB-2), Her 3 (ErbB-3) and Her 4 (ErbB-4). Bound by members of the epidermal growth factor family (EGF-family) of extracellular protein ligands, the HER receptors embedded in the cell membrane promote cell growth and division by turning genes on and off. The HER2 pathway stimulates cell proliferation if it normally functions; when HER2 is overexpressed, cell growth accelerates beyond its normal limits, which happens in some cancers, notably certain types of breast cancer.
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