MHC Class II HLA-DP/DQ/DR antibody (Biotin)

Catalog No. ABIN7200614

Product Details anti-MHC Class II HLA-DP/DQ/DR Antibody (Biotin)

Target: MHC Class II HLA-DP/DQ/DR (HLA-DP/DQ/DR)

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This MHC Class II HLA-DP/DQ/DR antibody is conjugated to Biotin

Application: Flow Cytometry (FACS)

Purpose: Anti-HLA-DR, DP, DQ Biotin Antibody

Characteristics: The clone IVA12 recognizes the shared epitopes of human leukocyte antigen (HLA) class II molecules HLA-DP, HLA-DQ and HLA-DR heterodimeric cell surface glycoproteins comprised of an α (heavy) chain and a β (light) chain. They are expressed on B cells, activated T cells, monocytes/macrophages, dendritic cells, and other non-professional antigen presenting cells (APCs). HLA-Class II expressing APCs specifically present antigens recognized by TCR/CD3 complex of CD4+ T cells. Reactive microglia and perivascular cells in multiple sclerosis lesions express all three types of HLA-Class II molecules, whereas microglia in the normal CNS express HLA-DR only.

Purification: Purified

Purity: >95 %

Grade: GMP Grade

Immunogen: Priess human B cell line

Clone: IVA12

Isotype: IgG1, kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS pH 7.2, 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: 2-8°C, Conjugated antibodies should never be frozen.

Target Details for MHC Class II HLA-DP/DQ/DR

Target: MHC Class II HLA-DP/DQ/DR (HLA-DP/DQ/DR)

Alternative Name: HLA-DR, DP, DQ (HLA-DP/DQ/DR Products)

Pathways: Human Leukocyte Antigen (HLA) in Adaptive Immune Response