nectin-3 antibody (AA 431-549) (Biotin)

Catalog No. ABIN715393

Product Details anti-nectin-3 Antibody (Biotin)

Target: nectin-3 (NECTIN3) (Nectin cell adhesion molecule 3 (NECTIN3))

Binding Specificity: AA 431-549

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This nectin-3 antibody is conjugated to Biotin

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Cross-Reactivity: Human, Mouse

Predicted Reactivity: Rat,Cow,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Nectin 3

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for 12 months.

Expiry Date: 12 months

Target Details for nectin-3

Target: nectin-3 (NECTIN3) (Nectin cell adhesion molecule 3 (NECTIN3))

Alternative Name: Nectin 3 (NECTIN3 Products)

Synonyms: PVRL3 antibody, CD113 antibody, CDW113 antibody, NECTIN-3 antibody, PPR3 antibody, PRR3 antibody, PVRR3 antibody, 2610301B19Rik antibody, 3000002N23Rik antibody, 4921513D19Rik antibody, AA407785 antibody, AU016832 antibody, AW538082 antibody, nectin cell adhesion molecule 3 antibody, poliovirus receptor-related 3 antibody, Nectin3 antibody, NECTIN3 antibody, PVRL3 antibody, nectin3 antibody

Background:

Synonyms: CD113, CDw113, DKFZP566B0846, FLJ90624, Nectin-3, Nectin3, Poliovirus receptor related 3, Poliovirus receptor related protein 3, Poliovirus receptor-related protein 3, PPR3, PRR3, PVRL 3, PVRL3, PVRL3_HUMAN, PVRR3.

Background: Nectins are immunoglobulin-like adhesion molecules that interact with afadin. Afadin is an actin filament-binding protein that connects nectins to the actin cytoskeleton. The nectin-afadin system organizes adherens junctions cooperatively with the cadherin-catenin system in epithelial cells.The nectin/PRR-family consists of four members, nectin-1, -2, -3 and -4. All the members of the nectin family have two or three slice variants. Nectin 3 is mainly expressed in testis and placental tissues and interacts in vivo with both long and short isoforms of afadin.

Gene ID: 25945

Pathways: Cell-Cell Junction Organization