KRT6A antibody (AA 253-352)

Catalog No. ABIN7193708

Product Details anti-KRT6A Antibody

Target: KRT6A (Keratin 6A (KRT6A))

Binding Specificity: AA 253-352

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This KRT6A antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunocytochemistry (ICC), Flow Cytometry (FACS)

Purpose: KRT6A Antibody

Purification: Purified antibody

Immunogen: Purified recombinant fragment of human KRT6A (AA: 253-352) expressed in E. Coli.

Clone: 7E3D1

Isotype: IgG2b

Application Details

Application Notes:

ELISA: 1/10000

FCM: 1/200 - 1/400

ICC: 1/200 - 1/1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Target Details for KRT6A

Target: KRT6A (Keratin 6A (KRT6A))

Alternative Name: KRT6A (KRT6A Products)

Background:

Description:

The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. As many as six of this type II cytokeratin (KRT6) have been identified, the multiplicity of the genes is attributed to successive gene duplication events. The genes are expressed with family members KRT16 and/or KRT17 in the filiform papillae of the tongue, the stratified epithelial lining of oral mucosa and esophagus, the outer root sheath of hair follicles, and the glandular epithelia. This KRT6 gene in particular encodes the most abundant isoform. Mutations in these genes have been associated with pachyonychia congenita. In addition, peptides from the C-terminal region of the protein have antimicrobial activity against bacterial pathogens. The type II cytokeratins are clustered in a region of chromosome 12q12-q13.

Aliases: KRT6A, K6A, K6C, K6D, PC3, CK6C, CK6D, CK-6C, CK-6E, KRT6C, KRT6D

Molecular Weight: 60kDa

Gene ID: 3853

UniProt: P02538