TIA1 antibody (AA 1-215)

Catalog No. ABIN7193566

Product Details anti-TIA1 Antibody

Target: TIA1 (TIA1 Cytotoxic Granule-Associated RNA Binding Protein (TIA1))

Binding Specificity: AA 1-215

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This TIA1 antibody is un-conjugated

Application: Immunohistochemistry (IHC), ELISA, Flow Cytometry (FACS), Immunocytochemistry (ICC)

Purpose: TIA1 Antibody

Purification: Purified antibody

Immunogen: Purified recombinant fragment of human TIA1 (AA: 1-215) expressed in E. Coli.

Clone: 3A3B9

Isotype: IgG1

Application Details

Application Notes:

ELISA: 1/10000

FCM: 1/200-1/400

ICC: 1/200 - 1/1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Target Details for TIA1

Target: TIA1 (TIA1 Cytotoxic Granule-Associated RNA Binding Protein (TIA1))

Alternative Name: TIA1 (TIA1 Products)

Background:

Description:

The product encoded by this gene is a member of a RNA-binding protein family and possesses nucleolytic activity against cytotoxic lymphocyte (CTL) target cells. It has been suggested that this protein may be involved in the induction of apoptosis as it preferentially recognizes poly(A) homopolymers and induces DNA fragmentation in CTL targets. The major granule-associated species is a 15- kDa protein that is thought to be derived from the carboxyl terminus of the 40- kDa product by proteolytic processing. Alternative splicing resulting in different isoforms has been found for this gene.

Aliases: WDM, TIA-1

Molecular Weight: 43kDa

Gene ID: 7072

UniProt: P31483