MSH2 antibody (AA 442-586)

Catalog No. ABIN7193496

Product Details anti-MSH2 Antibody

Target: MSH2 (Mismatch Repair Protein 2 (MSH2))

Binding Specificity: AA 442-586

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This MSH2 antibody is un-conjugated

Application: ELISA, Flow Cytometry (FACS)

Purpose: MSH2 Antibody

Purification: Purified antibody

Immunogen: Purified recombinant fragment of human MSH2 (AA: 442-586) expressed in E. Coli.

Clone: 4F10D6

Isotype: IgG2b

Application Details

Application Notes:

ELISA: 1/10000

FCM: 1/200 - 1/400

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Target Details for MSH2

Target: MSH2 (Mismatch Repair Protein 2 (MSH2))

Alternative Name: MSH2 (MSH2 Products)

Background:

Description:

This locus is frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). When cloned, it was discovered to be a human homolog of the E. coli mismatch repair gene mutS, consistent with the characteristic alterations in microsatellite sequences (RER+ phenotype) found in HNPCC. Two transcript variants encoding different isoforms have been found for this gene.

Aliases: FCC1, COCA1, HNPCC, LCFS2, hMSH2, HNPCC1

Molecular Weight: 104.7kDa

Gene ID: 4436

UniProt: P43246

Pathways: DNA Damage Repair, Production of Molecular Mediator of Immune Response