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PMS2 antibody (AA 748-851)

PMS2 Reactivity: Human WB, ELISA, ICC, FACS Host: Mouse Monoclonal 8E4G11 unconjugated
Catalog No. ABIN7193481
  • Target See all PMS2 Antibodies
    PMS2 (PMS2 Postmeiotic Segregation Increased 2 (S. Cerevisiae) (PMS2))
    Binding Specificity
    • 5
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 748-851
    Reactivity
    • 57
    • 10
    • 8
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Host
    • 45
    • 12
    Mouse
    Clonality
    • 36
    • 21
    Monoclonal
    Conjugate
    • 40
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    This PMS2 antibody is un-conjugated
    Application
    • 34
    • 25
    • 12
    • 12
    • 7
    • 6
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunocytochemistry (ICC), Flow Cytometry (FACS)
    Purpose
    PMS2 Antibody
    Purification
    Purified antibody
    Immunogen
    Purified recombinant fragment of human PMS2 (AA: 748-851) expressed in E. Coli.
    Clone
    8E4G11
    Isotype
    IgG2b
    Top Product
    Discover our top product PMS2 Primary Antibody
  • Application Notes

    ELISA: 1/10000

    FCM: 1/200 - 1/400

    ICC: 1/500 - 1/2000

    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified antibody in PBS with 0.05 % sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
  • Target
    PMS2 (PMS2 Postmeiotic Segregation Increased 2 (S. Cerevisiae) (PMS2))
    Alternative Name
    PMS2 (PMS2 Products)
    Synonyms
    HNPCC4 antibody, PMS2CL antibody, PMSL2 antibody, AW555130 antibody, Pmsl2 antibody, PMS1 homolog 2, mismatch repair system component antibody, PMS1 homolog2, mismatch repair system component antibody, mismatch repair endonuclease PMS2 antibody, PMS2 antibody, Pms2 antibody, LOC463257 antibody, LOC107984056 antibody
    Background

    Description:

    The protein encoded by this gene is a key component of the mismatch repair system that functions to correct DNA mismatches and small insertions and deletions that can occur during DNA replication and homologous recombination. This protein forms heterodimers with the gene product of the mutL homolog 1 (MLH1) gene to form the MutL-alpha heterodimer. The MutL-alpha heterodimer possesses an endonucleolytic activity that is activated following recognition of mismatches and insertion/deletion loops by the MutS-alpha and MutS-beta heterodimers, and is necessary for removal of the mismatched DNA. There is a DQHA(X)2E(X)4E motif found at the C-terminus of the protein encoded by this gene that forms part of the active site of the nuclease. Mutations in this gene have been associated with hereditary nonpolyposis colorectal cancer (HNPCC, also known as Lynch syndrome) and Turcot syndrome. [provided by RefSeq, Apr 2016]

    Aliases: MLH4, PMSL2, HNPCC4, PMS2CL

    Molecular Weight
    95.8kDa
    Gene ID
    5395
    UniProt
    P54278
    Pathways
    DNA Damage Repair, Production of Molecular Mediator of Immune Response
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