ATR antibody (AA 366-550)
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- Target See all ATR Antibodies
- ATR (ATR serine/threonine kinase (ATR))
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Binding Specificity
- AA 366-550
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Reactivity
- Human
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Host
- Mouse
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Clonality
- Monoclonal
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Conjugate
- This ATR antibody is un-conjugated
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Application
- ELISA, Western Blotting (WB), Flow Cytometry (FACS)
- Purification
- purified
- Immunogen
- Purified recombinant fragment of human ATR (AA: 366-550) expressed in E. coli.
- Clone
- 3G6D2
- Isotype
- IgG1
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- Application Notes
- WB:1:500 - 1:2000, FCM:1:200 - 1:400, ELISA:1:10000,
- Restrictions
- For Research Use only
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- Buffer
- Purified antibody in PBS with 0.05 % sodium azide
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- 4 °C/-20 °C
- Storage Comment
- 4°C, -20°C for long term storage
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- Target
- ATR (ATR serine/threonine kinase (ATR))
- Alternative Name
- ATR (ATR Products)
- Synonyms
- FCTCS antibody, FRP1 antibody, MEC1 antibody, SCKL antibody, SCKL1 antibody, ATR serine/threonine kinase antibody, ataxia telangiectasia and Rad3 related antibody, ATR antibody, Atr antibody
- Background
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Description: The protein encoded by this gene is a serine/threonine kinase and DNA damage sensor, activating cell cycle checkpoint signaling upon DNA stress. The encoded protein can phosphorylate and activate several proteins involved in the inhibition of DNA replication and mitosis, and can promote DNA repair, recombination, and apoptosis. This protein is also important for fragile site stability and centrosome duplication. Defects in this gene are a cause of Seckel syndrome 1.
Aliases: FRP1, MEC1, SCKL, FCTCS, SCKL1
- Molecular Weight
- 301 kDa
- Gene ID
- 545
- Pathways
- Positive Regulation of Response to DNA Damage Stimulus
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