HLA-B antibody (AA 209-295)
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- Target See all HLA-B Antibodies
- HLA-B (Major Histocompatibility Complex, Class I, B (HLA-B))
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Binding Specificity
- AA 209-295
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Reactivity
- Human
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Host
- Mouse
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Clonality
- Monoclonal
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Conjugate
- This HLA-B antibody is un-conjugated
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Application
- Western Blotting (WB), ELISA
- Purification
- purified
- Immunogen
- Purified recombinant fragment of human HLA-B (AA: 209-295) expressed in E. coli.
- Clone
- 4D4B6
- Isotype
- IgG1
- Top Product
- Discover our top product HLA-B Primary Antibody
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- Application Notes
- WB:1:500 - 1:2000, ELISA:1:10000,
- Restrictions
- For Research Use only
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- Buffer
- Purified antibody in PBS with 0.05 % sodium azide
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- 4 °C/-20 °C
- Storage Comment
- 4°C, -20°C for long term storage
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- Target
- HLA-B (Major Histocompatibility Complex, Class I, B (HLA-B))
- Alternative Name
- HLA-B (HLA-B Products)
- Synonyms
- AS antibody, HLAB antibody, SPDA1 antibody, mhc1b antibody, major histocompatibility complex, class I, B antibody, major histocompatibility complex nonclassical class Ib L homeolog antibody, HLA-B antibody, BOLA-B antibody, MAMU-B18 antibody, DKFZP469N1225 antibody, mhc1b.L antibody
- Background
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Description: HLA-B belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exon 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-B alleles have been described. [provided by RefSeq, Jul 2008]
Aliases: AS, HLAB, B-4901
- Molecular Weight
- 40.4 kDa
- Gene ID
- 3106
- Pathways
- Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Cancer Immune Checkpoints, Human Leukocyte Antigen (HLA) in Adaptive Immune Response
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