SETD2 antibody (AA 2054-2245)

Catalog No. ABIN7193416

Product Details anti-SETD2 Antibody

Target: SETD2 (SET Domain Containing 2 (SETD2))

Binding Specificity: AA 2054-2245

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This SETD2 antibody is un-conjugated

Application: ELISA, Flow Cytometry (FACS)

Purpose: SETD2 Antibody

Purification: Purified antibody

Immunogen: Purified recombinant fragment of human SETD2 (AA: 2054-2245) expressed in E. Coli.

Clone: 4G11E6

Isotype: IgG1

Application Details

Application Notes:

ELISA: 1/10000

FCM: 1/200 - 1/400

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Target Details for SETD2

Target: SETD2 (SET Domain Containing 2 (SETD2))

Alternative Name: SETD2 (SETD2 Products)

Synonyms: Kif9 antibody, HBP231 antibody, HIF-1 antibody, HIP-1 antibody, HYPB antibody, KMT3A antibody, SET2 antibody, p231HBP antibody, SET domain containing 2 antibody, Setd2 antibody, SETD2 antibody

Background:

Description:

Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. This gene encodes a protein belonging to a class of huntingtin interacting proteins characterized by WW motifs. This protein is a histone methyltransferase that is specific for lysine-36 of histone H3, and methylation of this residue is associated with active chromatin. This protein also contains a novel transcriptional activation domain and has been found associated with hyperphosphorylated RNA polymerase II. [provided by RefSeq, Aug 2008]

Aliases: LLS, HYPB, SET2, HIF-1, HIP-1, KMT3A, HBP231, HSPC069, p231HBP

Molecular Weight: 287.6kDa

Gene ID: 29072

Pathways: Tube Formation