PRNP antibody (AA 23-230)

Catalog No. ABIN7193415

Product Details anti-PRNP Antibody

Target: PRNP (Prion Protein (PRNP))

Binding Specificity: AA 23-230

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This PRNP antibody is un-conjugated

Application: ELISA, Flow Cytometry (FACS)

Purpose: CD230 Antibody

Purification: Purified antibody

Immunogen: Purified recombinant fragment of human CD230 (AA: 23-230) expressed in E. Coli.

Clone: 3G10G9

Isotype: IgG1

Application Details

Application Notes:

ELISA: 1/10000

FCM: 1/200 - 1/400

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Target Details for PRNP

Target: PRNP (Prion Protein (PRNP))

Alternative Name: CD230 (PRNP Products)

Background:

Description:

The protein encoded by this gene is a membrane glycosylphosphatidylinositol-anchored glycoprotein that tends to aggregate into rod-like structures. The encoded protein contains a highly unstable region of five tandem octapeptide repeats. This gene is found on chromosome 20, approximately 20 kbp upstream of a gene which encodes a biochemically and structurally similar protein to the one encoded by this gene. Mutations in the repeat region as well as elsewhere in this gene have been associated with Creutzfeldt-Jakob disease, fatal familial insomnia, Gerstmann-Straussler disease, Huntington disease-like 1, and kuru. An overlapping open reading frame has been found for this gene that encodes a smaller, structurally unrelated protein, AltPrp. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]

Aliases: PRNP, CJD, GSS, PrP, ASCR, KURU, PRIP, PrPc, AltPrP, p27-30, PrP27-30, PrP33-35C

Molecular Weight: 27.7kDa

Gene ID: 5621

UniProt: P04156

Pathways: Transition Metal Ion Homeostasis, Activated T Cell Proliferation