XIAP antibody (AA 1-268)
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- Target See all XIAP Antibodies
- XIAP (X-Linked Inhibitor of Apoptosis (XIAP))
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Binding Specificity
- AA 1-268
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Reactivity
- Human
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Host
- Mouse
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Clonality
- Monoclonal
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Conjugate
- This XIAP antibody is un-conjugated
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Application
- ELISA, Flow Cytometry (FACS)
- Purpose
- XIAP Antibody
- Purification
- Purified antibody
- Immunogen
- Purified recombinant fragment of human XIAP (AA: 1-268) expressed in E. Coli.
- Clone
- 4C12G10
- Isotype
- IgG2b
- Top Product
- Discover our top product XIAP Primary Antibody
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- Application Notes
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ELISA: 1/10000
FCM: 1/200 - 1/400
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- Purified antibody in PBS with 0.05 % sodium azide.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- 4 °C,-20 °C
- Storage Comment
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
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- Target
- XIAP (X-Linked Inhibitor of Apoptosis (XIAP))
- Alternative Name
- XIAP (XIAP Products)
- Background
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Description:
This gene encodes a protein that belongs to a family of apoptotic suppressor proteins. Members of this family share a conserved motif termed, baculovirus IAP repeat, which is necessary for their anti-apoptotic function. This protein functions through binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2 and inhibits apoptosis induced by menadione, a potent inducer of free radicals, and interleukin 1-beta converting enzyme. This protein also inhibits at least two members of the caspase family of cell-death proteases, caspase-3 and caspase-7. Mutations in this gene are the cause of X-linked lymphoproliferative syndrome. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 2 and 11.[provided by RefSeq, Feb 2011]
Aliases: API3, ILP1, MIHA, XLP2, BIRC4, IAP-3, hIAP3, hIAP-3
- Molecular Weight
- 56.7kDa
- Gene ID
- 331
- UniProt
- P98170
- Pathways
- Apoptosis, Caspase Cascade in Apoptosis, Transition Metal Ion Homeostasis
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