MTA1 antibody (AA 541-715)

Catalog No. ABIN7193370

Product Details anti-MTA1 Antibody

Target: MTA1 (Metastasis Associated 1 (MTA1))

Binding Specificity: AA 541-715

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This MTA1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Purpose: MTA1 Antibody

Purification: Purified antibody

Immunogen: Purified recombinant fragment of human MTA1 (AA: 541-715) expressed in E. Coli.

Clone: 6B1E9

Isotype: IgG2b

Application Details

Application Notes:

ELISA: 1/10000

FCM: 1/200 - 1/400

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Target Details for MTA1

Target: MTA1 (Metastasis Associated 1 (MTA1))

Alternative Name: MTA1 (MTA1 Products)

Synonyms: Tex22 antibody, metastasis associated 1 antibody, metastasis associated 1 L homeolog antibody, MTA1 antibody, Mta1 antibody, mta1.L antibody

Background:

This gene encodes a protein that was identified in a screen for genes expressed in metastatic cells, specifically, mammary adenocarcinoma cell lines. Expression of this gene has been correlated with the metastatic potential of at least two types of carcinomas although it is also expressed in many normal tissues. The role it plays in metastasis is unclear. It was initially thought to be the 70kD component of a nucleosome remodeling deacetylase complex, NuRD, but it is more likely that this component is a different but very similar protein. These two proteins are so closely related, though, that they share the same types of domains. These domains include two DNA binding domains, a dimerization domain, and a domain commonly found in proteins that methylate DNA. The profile and activity of this gene product suggest that it is involved in regulating transcription and that this may be accomplished by chromatin remodeling. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]

Molecular Weight: 80.8kDa

Gene ID: 9112

UniProt: Q13330

Pathways: Chromatin Binding