IL5RA antibody (AA 21-196)

Catalog No. ABIN7193317

Product Details anti-IL5RA Antibody

Target: IL5RA (Interleukin 5 Receptor, alpha (IL5RA))

Binding Specificity: AA 21-196

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This IL5RA antibody is un-conjugated

Application: ELISA, Flow Cytometry (FACS)

Purpose: CD125 Antibody

Purification: Purified antibody

Immunogen: Purified recombinant fragment of human CD125 (AA: 21-196) expressed in E. Coli.

Clone: 5E12F5D6

Isotype: IgG1

Application Details

Application Notes:

ELISA: 1/10000

FCM: 1/200 - 1/400

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Target Details for IL5RA

Target: IL5RA (Interleukin 5 Receptor, alpha (IL5RA))

Alternative Name: CD125 (IL5RA Products)

Synonyms: MGC86517 antibody, IL5RA antibody, il5r antibody, cdw125 antibody, hsil5r3 antibody, gpIL-5ra antibody, CD125 antibody, CDw125 antibody, HSIL5R3 antibody, IL5R antibody, Il5r antibody, interleukin 5 receptor subunit alpha L homeolog antibody, interleukin 5 receptor subunit alpha antibody, interleukin 5 receptor, alpha antibody, il5ra.L antibody, IL5RA antibody, il5ra antibody, Il5ra antibody

Background:

Description:

The protein encoded by this gene is an interleukin 5 specific subunit of a heterodimeric cytokine receptor. The receptor is comprised of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for interleukin 3 (IL3), colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5 (IL5). The binding of this protein to IL5 depends on the beta subunit. The beta subunit is activated by the ligand binding, and is required for the biological activities of IL5. This protein has been found to interact with syndecan binding protein (syntenin), which is required for IL5 mediated activation of the transcription factor SOX4. Several alternatively spliced transcript variants encoding four distinct isoforms have been reported.

Aliases: IL5RA, IL5R, CDw125, HSIL5R3

Molecular Weight: 47.7kDa

Gene ID: 3568

Pathways: JAK-STAT Signaling