CXCR2 antibody

Catalog No. ABIN7193273

Product Details anti-CXCR2 Antibody

Target: CXCR2 (Chemokine (C-X-C Motif) Receptor 2 (CXCR2))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CXCR2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Flow Cytometry (FACS), Immunocytochemistry (ICC), Neutralization (Neut)

Purification: purified

Immunogen: Purified recombinant fragment of human CD182 expressed in E. coli.

Clone: 7E9H12

Isotype: IgG1

Application Details

Application Notes: ELISA: 1:10000, WB: 1:500 - 1:2000, FCM: 1:200 - 1:400, ICC: N/A, IHC: 1:200 - 1:1000

Restrictions: For Research Use only

Handling

Buffer: Purified antibody in PBS with 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C/-20 °C

Storage Comment: 4°C, -20°C for long term storage

Target Details for CXCR2

Target: CXCR2 (Chemokine (C-X-C Motif) Receptor 2 (CXCR2))

Alternative Name: CD182 (CXCR2 Products)

Synonyms: CD182 antibody, CDw128b antibody, CMKAR2 antibody, IL8R2 antibody, IL8RA antibody, IL8RB antibody, CXC-R2 antibody, CXCR-2 antibody, CD128 antibody, CDw128 antibody, Cmkar2 antibody, Gpcr16 antibody, IL-8Rh antibody, IL-8rb antibody, Il8rb antibody, mIL-8RH antibody, C-X-C motif chemokine receptor 2 antibody, chemokine (C-X-C motif) receptor 2 antibody, Cxcr2 antibody, CXCR2 antibody

Background:

Description: The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. This receptor also binds to chemokine (C-X-C motif) ligand 1 (CXCL1/MGSA), a protein with melanoma growth stimulating activity, and has been shown to be a major component required for serum-dependent melanoma cell growth. This receptor mediates neutrophil migration to sites of inflammation. The angiogenic effects of IL8 in intestinal microvascular endothelial cells are found to be mediated by this receptor. Knockout studies in mice suggested that this receptor controls the positioning of oligodendrocyte precursors in developing spinal cord by arresting their migration. This gene, IL8RA, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36. Alternatively spliced variants, encoding the same protein, have been identified.

Aliases: CXCR2, IL8R2, IL8RA, IL8RB, CMKAR2, CDw128b

Molecular Weight: 40.8 kDa

Gene ID: 3579

Pathways: cAMP Metabolic Process