DLC1 antibody (AA 1-80) (Biotin)

Catalog No. ABIN714958

Product Details anti-DLC1 Antibody (Biotin)

Target: DLC1 (Deleted in Liver Cancer 1 (DLC1))

Binding Specificity: AA 1-80

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DLC1 antibody is conjugated to Biotin

Application: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Predicted Reactivity: Human,Mouse,Rat,Cow,Pig,Horse,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human DLC1

Isotype: IgG

Application Details

Application Notes: IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for 12 months.

Expiry Date: 12 months

Target Details for DLC1

Target: DLC1 (Deleted in Liver Cancer 1 (DLC1))

Alternative Name: DLC1 (DLC1 Products)

Synonyms: ARHGAP7 antibody, HP antibody, STARD12 antibody, p122-RhoGAP antibody, rhogap7 antibody, DLC-1 antibody, StARD12 antibody, Dlc-1 antibody, A730069N07Rik antibody, Arhgap7 antibody, dlc-1 antibody, RhoGAP antibody, Dlc1 antibody, DLC1 Rho GTPase activating protein antibody, DLC1 Rho GTPase activating protein S homeolog antibody, rho GTPase-activating protein 7 antibody, deleted in liver cancer 1 antibody, DLC1 antibody, dlc1.S antibody, dlc1 antibody, LOC100456847 antibody, Dlc1 antibody, LOC100729904 antibody

Background:

Synonyms: LC8, PIN, DLC1, DLC8, LC8a, DNCL1, hdlc1, DNCLC1, Dynein light chain 1, cytoplasmic, 8 kDa dynein light chain, Dynein light chain LC8-type 1, Protein inhibitor of neuronal nitric oxide synthase, DYNLL1

Background: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures. Binds and inhibits the catalytic activity of neuronal nitric oxide synthase. Promotes transactivation functions of ESR1 and plays a role in the nuclear localization of ESR1. Regulates apoptotic activities of BCL2L11 by sequestering it to microtubules. Upon apoptotic stimuli the BCL2L11-DYNLL1 complex dissociates from cytoplasmic dynein and translocates to mitochondria and sequesters BCL2 thus neutralizing its antiapoptotic activity.

Gene ID: 8655

UniProt: P63167

Pathways: Tube Formation, Positive Regulation of Endopeptidase Activity