GCH1 antibody

Catalog No. ABIN7190766

Product Details anti-GCH1 Antibody

Target: GCH1 (GTP Cyclohydrolase 1 (GCH1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GCH1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Cross-Reactivity: Human

Purification: Antigen affinity purification

Immunogen: Synthetic peptide of Human GCH1

Isotype: IgG

Application Details

Application Notes: ELISA:1:1000-1:2000, WB:1:200-1:1000, IHC:1:5-1:20,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: -20 °C, pH 7.4 PBS, 0.05 % Sodium azide, 40 % Glycerol

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for GCH1

Target: GCH1 (GTP Cyclohydrolase 1 (GCH1))

Alternative Name: GCH1 (GCH1 Products)

Synonyms: DYT14 antibody, DYT5 antibody, DYT5a antibody, GCH antibody, GTP-CH-1 antibody, GTPCH1 antibody, HPABH4B antibody, GTP-CH antibody, GTPCH antibody, Gch antibody, MGC89622 antibody, gch1a antibody, wu:fc16b10 antibody, zgc:195269 antibody, GTP cyclohydrolase 1 antibody, GTP cyclohydrolase 1-like antibody, GCH1 antibody, Gch1 antibody, gch1 antibody, Weevi_1190 antibody, Halhy_0838 antibody, Sinme_1220 antibody, Sphch_1077 antibody, LOC100136794 antibody

Background:

Background: This gene encodes a member of the GTP cyclohydrolase family. The encoded protein is the first and rate-limiting enzyme in tetrahydrobiopterin (BH4) biosynthesis, catalyzing the conversion of GTP into 7,8-dihydroneopterin triphosphate. BH4 is an essential cofactor required by aromatic amino acid hydroxylases as well as nitric oxide synthases. Mutations in this gene are associated with malignant hyperphenylalaninemia and dopa-responsive dystonia. Several alternatively spliced transcript variants encoding different isoforms have been described, however, not all variants give rise to a functional enzyme.

Aliases: dystonia 14 antibody, DYT 5 antibody, DYT14 antibody, DYT5 antibody, DYT5a antibody, GCH 1 antibody, GCH antibody, Gch1 antibody, GCH1_HUMAN antibody, GTP CH 1 antibody, GTP CH I antibody, GTP cyclohydrolase 1 (dopa responsive dystonia) antibody, GTP cyclohydrolase 1 antibody, GTP cyclohydrolase I antibody, GTP-CH-I antibody, GTPCH 1 antibody, GTPCH1 antibody, Guanosine 5' triphosphate cyclohydrolase I antibody, HPABH4B antibody

UniProt: P30793