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ITGAV/ITGB6 antibody

ITGAV/ITGB6 Reactivity: Human, Mouse, Rat FACS, WB, IF (cc), IF (p), IHC (fro), ELISA, IHC (p) Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN714806
  • Target See all ITGAV/ITGB6 products
    ITGAV/ITGB6 (Integrin AlphaV Beta6 (ITGAV/ITGB6))
    Reactivity
    • 19
    • 16
    • 16
    • 1
    Human, Mouse, Rat
    Host
    • 15
    • 3
    • 1
    Rabbit
    Clonality
    • 15
    • 4
    Polyclonal
    Conjugate
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This ITGAV/ITGB6 antibody is un-conjugated
    Application
    • 17
    • 16
    • 12
    • 12
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Flow Cytometry (FACS), Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Cross-Reactivity
    Human, Mouse, Rat
    Purification
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human Integrin Alpha V + Beta 6
    Isotype
    IgG
  • Application Notes
    WB 1:300-5000
    ELISA 1:500-1000
    FCM 1:20-100
    IHC-P 1:200-400
    IHC-F 1:100-500
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    Expiry Date
    12 months
  • Cargnoni, Farigu, Cotti Piccinelli, Bonassi Signoroni, Romele, Vanosi, Toschi, Cesari, Barros SantAnna, Magatti, Silini, Parolini: "Effect of human amniotic epithelial cells on pro-fibrogenic resident hepatic cells in a rat model of liver fibrosis." in: Journal of cellular and molecular medicine, Vol. 22, Issue 2, pp. 1202-1213, (2017) (PubMed).

    Gao, Gao, Zhang, Liu, Jia, Zhu, Wang, Liu: "A near-infrared phthalocyanine dye-labeled agent for integrin ?v?6-targeted theranostics of pancreatic cancer." in: Biomaterials, Vol. 53, pp. 229-38, (2015) (PubMed).

    Li, Huang, Gao, Chen, Zhang, Zheng: "Scutellarin inhibits the growth and invasion of human tongue squamous carcinoma through the inhibition of matrix metalloproteinase-2 and -9 and αvβ6 integrin." in: International journal of oncology, Vol. 42, Issue 5, pp. 1674-81, (2013) (PubMed).

  • Target
    ITGAV/ITGB6 (Integrin AlphaV Beta6 (ITGAV/ITGB6))
    Alternative Name
    Integrin Alpha V + Beta 6 (ITGAV/ITGB6 Products)
    Background

    Synonyms: CD51, Integrin alpha-V light chain, integrin, alpha V vitronectin receptor, alpha polypeptide, antigen CD51, Integrin, alpha V, Integrin, beta 6, ITAV_HUMAN, ITGAV, ITGB6, Vitronectin receptor subunit alpha.

    Background: Integrins are heterodimeric cell surface receptors composed of alpha and beta subunits, which mediate cell-cell and cell-extracellular matrix attachments. Aberrant integrin expression has been found in many epithelial tumours. Changes in integrin expression have been shown to be important for the growth and early metastatic capacity of melanoma cells. Integrin alpha-v beta-6 is upregulated in cancers and during tissue remodelling but is absent from resting adult tissues. Integrin alpha-v beta-6 promotes invasion and correlates with poor survival and therefore makes a promising therapeutic target.

    Gene ID
    36853694
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