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GRK6 antibody (N-Term)

GRK6 Reactivity: Human WB, ELISA, IF Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN7184455
  • Target See all GRK6 Antibodies
    GRK6 (G Protein-Coupled Receptor Kinase 6 (GRK6))
    Binding Specificity
    • 8
    • 4
    • 4
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reactivity
    • 38
    • 23
    • 17
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    Human
    Host
    • 33
    • 5
    Rabbit
    Clonality
    • 35
    • 3
    Polyclonal
    Conjugate
    • 26
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This GRK6 antibody is un-conjugated
    Application
    • 30
    • 16
    • 14
    • 5
    • 4
    • 3
    • 2
    Western Blotting (WB), ELISA, Immunofluorescence (IF)
    Cross-Reactivity
    Human, Mouse, Rat
    Purification
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
    Immunogen
    Synthesized peptide derived from N-terminal of Human GRK6.
    Isotype
    IgG
    Top Product
    Discover our top product GRK6 Primary Antibody
  • Application Notes
    WB:1:500-1:3000, IF:1:100-1:500,
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C,-80 °C
    Storage Comment
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Target
    GRK6 (G Protein-Coupled Receptor Kinase 6 (GRK6))
    Alternative Name
    GRK6 (GRK6 Products)
    Synonyms
    MGC83187 antibody, GRK6 antibody, GPRK6 antibody, Gprk6 antibody, G protein-coupled receptor kinase 6 antibody, G protein-coupled receptor kinase 6 S homeolog antibody, GRK6 antibody, grk6.S antibody, grk6 antibody, Grk6 antibody
    Background

    Background: Specifically phosphorylates the activated forms of G protein-coupled receptors. Such receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their desensitization. Seems to be involved in the desensitization of D2-like dopamine receptors in striatum and chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis By similarity. Phosphorylates rhodopsin (RHO) (in vitro) and a non G-protein-coupled receptor: LRP6 during Wnt signaling (in vitro).

    Benovic J.L., J. Biol. Chem. 268:19521-19527(1993).
    Haribabu B., Proc. Natl. Acad. Sci. U.S.A. 90:9398-9402(1993).
    Stoffel R.H., J. Biol. Chem. 269:27791-27794(1994).

    Aliases: FLJ32135 antibody, G protein coupled receptor kinase 6 antibody, G protein coupled receptor kinase GRK6 antibody, G protein-coupled receptor kinase 6 antibody, G protein-coupled receptor kinase GRK6 antibody, Gprk6 antibody, Grk6 antibody, GRK6_HUMAN antibody

    UniProt
    P43250
    Pathways
    Myometrial Relaxation and Contraction, Regulation of G-Protein Coupled Receptor Protein Signaling, CXCR4-mediated Signaling Events, Negative Regulation of Transporter Activity
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