TEAD3 antibody

Catalog No. ABIN7184247

Product Details anti-TEAD3 Antibody

Target: TEAD3 (TEA Domain Family Member 3 (TEAD3))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TEAD3 antibody is un-conjugated

Application: ELISA, Western Blotting (WB)

Cross-Reactivity: Human

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from internal of Human TEAD3.

Isotype: IgG

Application Details

Application Notes: WB:1:500-1:3000,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for TEAD3

Target: TEAD3 (TEA Domain Family Member 3 (TEAD3))

Alternative Name: TEAD3 (TEAD3 Products)

Synonyms: DTEF-1 antibody, TEF-5 antibody, ETFR-1 antibody, TEAD-3 antibody, TEAD5 antibody, TEF5 antibody, Tcf13r2 antibody, cb882 antibody, tead3 antibody, TEA domain transcription factor 3 antibody, TEA domain family member 3 antibody, TEA domain family member 3 a antibody, tubby like protein 1 antibody, TEAD3 antibody, Tead3 antibody, tead3a antibody, TULP1 antibody

Background:

Background: Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds to multiple functional elements of the human chorionic somatomammotropin-B gene enhancer.

Jacquemin P., J. Biol. Chem. 272:12928-12937(1997).
Mungall A.J., Nature 425:805-811(2003).
Zhao B., Genes Dev. 22:1962-1971(2008).

Aliases: DTEF 1 antibody, DTEF-1 antibody, DTEF1 antibody, ETFR 1 antibody, ETFR1 antibody, TEA domain family member 3 antibody, TEA domain family member 5 antibody, TEAD 3 antibody, TEAD-3 antibody, Tead3 antibody, TEAD3_HUMAN antibody, TEAD5 antibody, TEF 5 antibody, TEF5 antibody, Transcriptional enhancer factor 5 antibody, Transcriptional enhancer factor TEF 5 (DTEF 1) antibody, Transcriptional enhancer factor TEF 5 antibody, Transcriptional enhancer factor TEF-5 antibody

UniProt: Q99594

Pathways: Regulation of Lipid Metabolism by PPARalpha