PPP1R16B antibody

Catalog No. ABIN7183999

Product Details anti-PPP1R16B Antibody

Target: PPP1R16B (Protein Phosphatase 1, Regulatory Subunit 16B (PPP1R16B))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PPP1R16B antibody is un-conjugated

Application: ELISA, Western Blotting (WB)

Cross-Reactivity: Human

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from internal of Human PPP1R16B.

Isotype: IgG

Application Details

Application Notes: WB:1:500-1:3000,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for PPP1R16B

Target: PPP1R16B (Protein Phosphatase 1, Regulatory Subunit 16B (PPP1R16B))

Alternative Name: PPP1R16B (PPP1R16B Products)

Synonyms: ANKRD4 antibody, C130078N17Rik antibody, TIMAP antibody, Wdt4 antibody, protein phosphatase 1, regulatory (inhibitor) subunit 16B antibody, protein phosphatase 1 regulatory subunit 16B antibody, Ppp1r16b antibody, PPP1R16B antibody

Background:

Background: Regulator of protein phosphatase 1 (PP1) that acts as a positive regulator of pulmonary endothelial cell (EC) barrier function. Involved in PKA-mediated moesin dephosphorylation which is important in EC barrier protection against thrombin stimulation. Promotes the interaction of PPP1CA with RPSA/LAMR1 and in turn facilitates the dephosphorylation of RPSA/LAMR1. Involved in the regulation of endothelial cell filopodia extension. May be a downstream target for TGF-beta1 signaling cascade in endothelial cells.

Cao W., Am. J. Physiol. 283:C327-C337(2002).
Nagase T., DNA Res. 5:355-364(1998).
Nakajima D., DNA Res. 9:99-106(2002).

Aliases: ANKRD4 antibody, Ankyrin repeat domain containing protein 4 antibody, ankyrin repeat domain protein 4 antibody, Ankyrin repeat domain-containing protein 4 antibody, CAAX box protein TIMAP antibody, hTIMAP antibody, KIAA0823 antibody, PP16B_HUMAN antibody, PPP1R16B antibody, Protein phosphatase 1 regulatory inhibitor subunit 16B antibody, protein phosphatase 1, regulatory (inhibitor) subunit 16B antibody, TGF beta inhibited membrane associated protein antibody, TGF-beta-inhibited membrane-associated protein antibody, TIMAP antibody

UniProt: Q96T49