beta Synuclein antibody

Catalog No. ABIN7182802

Product Details anti-beta Synuclein Antibody

Target: beta Synuclein (SNCB) (Synuclein, beta (SNCB))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This beta Synuclein antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Cross-Reactivity: Human, Mouse, Rat

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from Human Synuclein beta antibody.

Isotype: IgG

Application Details

Application Notes: WB:1:500-1:3000, IHC:1:50-1:100, IF:1:100-1:500,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for beta Synuclein

Target: beta Synuclein (SNCB) (Synuclein, beta (SNCB))

Alternative Name: SNCB (SNCB Products)

Synonyms: AI838531 antibody, betaSYN antibody, zgc:66343 antibody, sncb antibody, MGC75784 antibody, LOC619281 antibody, SNCB antibody, syub antibody, synuclein beta antibody, synuclein, beta antibody, synuclein beta L homeolog antibody, Beta-synuclein antibody, SNCB antibody, Sncb antibody, sncb antibody, sncb.L antibody, syub antibody

Background:

Background: Non-amyloid component of senile plaques found in Alzheimer disease. Could act as a regulator of SNCA aggregation process. Protects neurons from staurosporine and 6-hydroxy dopamine (6OHDA)-stimulated caspase activation in a p53/TP53-dependent manner. Contributes to restore the SNCA anti-apoptotic function abolished by 6OHDA. Not found in the Lewy bodies associated with Parkinson disease.

Yuxin Fan, Hum. Mol. Genet., Oct 2006, 15: 3002 - 3011.
Makoto Hashimoto, J. Biol. Chem., May 2004, 279: 23622 - 23629.
Cristine Alves da Costa, J. Biol. Chem., Sep 2003, 278: 37330 - 37335.
Heather Snyder, J. Biol. Chem., Mar 2005, 280: 7562 - 7569.

Aliases: 14 kDa brain-specific protein antibody, Beta-synuclein antibody, Phosphoneuroprotein 14 antibody, PNP14 antibody, Sncb antibody, Synuclein beta antibody, SYUB_HUMAN antibody

UniProt: Q16143