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CLNS1A antibody (C-Term)

CLNS1A Reactivity: Human WB, ELISA Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN7180144
  • Target See all CLNS1A Antibodies
    CLNS1A (Chloride Channel, Nucleotide-Sensitive, 1A (CLNS1A))
    Binding Specificity
    • 7
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reactivity
    • 42
    • 21
    • 19
    • 4
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Host
    • 39
    • 3
    Rabbit
    Clonality
    • 39
    • 3
    Polyclonal
    Conjugate
    • 22
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This CLNS1A antibody is un-conjugated
    Application
    • 35
    • 13
    • 7
    • 6
    • 5
    • 4
    • 3
    • 3
    • 3
    • 3
    • 2
    • 1
    Western Blotting (WB), ELISA
    Cross-Reactivity
    Human
    Purification
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
    Immunogen
    Synthesized peptide derived from C-terminal of Human CLNS1A.
    Isotype
    IgG
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  • Application Notes
    WB:1:500-1:3000,
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C,-80 °C
    Storage Comment
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Target
    CLNS1A (Chloride Channel, Nucleotide-Sensitive, 1A (CLNS1A))
    Alternative Name
    CLNS1A (CLNS1A Products)
    Synonyms
    CLCI antibody, CLNS1B antibody, ICln antibody, 2610036D06Rik antibody, 2610100O04Rik antibody, Clci antibody, Clcni antibody, ICLN antibody, Icln antibody, pICln antibody, clci antibody, clns1b antibody, icln antibody, pIcIn antibody, chloride nucleotide-sensitive channel 1A antibody, chloride channel, nucleotide-sensitive, 1A antibody, chloride channel, nucleotide-sensitive, 1A L homeolog antibody, CLNS1A antibody, Clns1a antibody, clns1a.L antibody, clns1a antibody
    Background

    Background: Chaperone that regulates the assembly of spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus. May also indirectly participate in cellular volume control by activation of a swelling-induced chloride conductance pathway.

    Buyse G., Biochem. Biophys. Res. Commun. 218:822-827(1996).
    Anquita J., Biochem. Biophys. Res. Commun. 208:89-95(1995).
    Lamb F.S., Submitted (JUL-1996) to the EMBL/GenBank/DDBJ databases.

    Aliases: Chloride channel antibody, Chloride channel nucleotide sensitive 1A antibody, Chloride channel regulatory protein antibody, Chloride conductance regulator, volume sensitive antibody, Chloride conductance regulatory protein ICln antibody, Chloride ion current inducer protein antibody, ClCI antibody, CLNS 1A antibody, Clns1a antibody, CLNS1B antibody, I(Cln) antibody, ICln antibody, ICLN_HUMAN antibody, Methylosome subunit pICln antibody, nucleotide sensitive 1A antibody, Reticulocyte pICln antibody, Reticulocyte protein ICln antibody

    UniProt
    P54105
    Pathways
    Ribonucleoprotein Complex Subunit Organization
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