Vitamin D Receptor antibody (Ser51)

Catalog No. ABIN7180105

Product Details anti-Vitamin D Receptor Antibody

Target: Vitamin D Receptor (VDR)

Binding Specificity: Ser51

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Vitamin D Receptor antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Cross-Reactivity: Human, Mouse

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized non-phosphopeptide derived from Human Vitamin D3 Receptor around the phosphorylation site of serine 51 (R-R-S(p)-M-K).

Isotype: IgG

Application Details

Application Notes: WB:1:500-1:3000,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for Vitamin D Receptor

Target: Vitamin D Receptor (VDR)

Alternative Name: VDR (VDR Products)

Synonyms: vdrbeta antibody, vdr0 antibody, LOC100136219 antibody, NR1I1-B antibody, gb:dq017633 antibody, vdr-b antibody, Ci-VDR-b antibody, VDR antibody, LOC100221284 antibody, vdr-A antibody, xVDR antibody, Nr1i1 antibody, vdr antibody, NR1I1 antibody, PPP1R163 antibody, vitamin D (1,25- dihydroxyvitamin D3) receptor antibody, vitamin D receptor antibody, vitamin D3 receptor A antibody, vitamin D receptor b antibody, nuclear receptor VDR-b antibody, vitamin D (1,25- dihydroxyvitamin D3) receptor L homeolog antibody, vitamin D (1,25-dihydroxyvitamin D3) receptor antibody, vitamin D receptor a antibody, vdr antibody, vdr0 antibody, VDR antibody, LOC100136219 antibody, vdrb antibody, vdr-b antibody, vdr.L antibody, Vdr antibody, vdra antibody

Target Type: Chemical

Background:

Background: Nuclear hormone receptor. Transcription factor that mediates the action of vitamin D3 by controlling the expression of hormone sensitive genes. Regulates transcription of hormone sensitive genes via its association with the WINAC complex, a chromatin-remodeling complex. Recruited to promoters via its interaction with the WINAC complex subunit BAZ1B/WSTF, which mediates the interaction with acetylated histones, an essential step for VDR-promoter association. Plays a central role in calcium homeostasis.

Baker A.R., Proc. Natl. Acad. Sci. U.S.A. 85:3294-3298(1988).
Goto H., Biochim. Biophys. Acta 1132:103-108(1992).
Miyamoto K., Mol. Endocrinol. 11:1165-1179(1997).

Aliases: 1 25 dihydroxyvitamin D3 receptor antibody, 1 antibody, 1,25 dihydroxyvitamin D3 receptor antibody, 1,25-@dihydroxyvitamin D3 receptor antibody, 25-dihydroxyvitamin D3 receptor antibody, Member 1 antibody, NR1I1 antibody, Nuclear receptor subfamily 1 group I member 1 antibody, PPP1R163 antibody, Protein phosphatase 1, regulatory subunit 163 antibody, VDR antibody, VDR_HUMAN antibody, Vitamin D (1,25- dihydroxyvitamin D3) receptor antibody, Vitamin D hormone receptor antibody, Vitamin D nuclear receptor variant 1 antibody, Vitamin D receptor antibody, Vitamin D3 receptor antibody

UniProt: P11473

Pathways: Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway