Phospholipase C gamma 1 antibody (Tyr771)

Catalog No. ABIN7180075

Product Details anti-Phospholipase C gamma 1 Antibody

Target: Phospholipase C gamma 1 (PLCG1) (phospholipase C, gamma 1 (PLCG1))

Binding Specificity: Tyr771

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Phospholipase C gamma 1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Cross-Reactivity: Human, Mouse, Rat

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized non-phosphopeptide derived from Human PLCG1 around the phosphorylation site of tyrosine 771 (P-D-Y-G-A).

Isotype: IgG

Application Details

Application Notes: WB:1:500-1:3000, IHC:1:50-1:100,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for Phospholipase C gamma 1

Target: Phospholipase C gamma 1 (PLCG1) (phospholipase C, gamma 1 (PLCG1))

Alternative Name: PLCG1 (PLCG1 Products)

Synonyms: NCKAP3 antibody, PLC-II antibody, PLC1 antibody, PLC148 antibody, PLCgamma1 antibody, plc1 antibody, nckap3 antibody, plc-ii antibody, plc148 antibody, plcgamma1 antibody, PPLCA antibody, AI894140 antibody, Cded antibody, Plc-1 antibody, Plc-gamma1 antibody, Plcg-1 antibody, fj46f04 antibody, wu:fj46f04 antibody, wu:fj57a05 antibody, phospholipase C gamma 1 antibody, phospholipase C gamma 1 L homeolog antibody, 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 antibody, phospholipase C, gamma 1 antibody, PLCG1 antibody, plcg1.L antibody, LOC100633163 antibody, Plcg1 antibody, plcg1 antibody

Background:

Background: Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. Becomes activated in response to ligand-mediated activation of receptor-type tyrosine kinases, such as PDGFRA, PDGFRB, FGFR1, FGFR2, FGFR3 and FGFR4. Plays a role in actin reorganization and cell migration.

Denis Tvorogov, J. Cell Sci., Feb 2005, 118: 601 - 610.
Brenda J. Irvin, Mol. Cell. Biol., Dec 2000, 20: 9149 - 9161.
Benoit Poulin, J. Biol. Chem., Feb 2000, 275: 6411.
Ichiro Nakamura, J. Cell Biol., Jan 2001, 152: 361.

Aliases: 1 phosphatidyl D myo inositol 4 5 bisphosphate antibody, 1 phosphatidylinositol 4 5 bisphosphate phosphodiesterase gamma 1 antibody, 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1 antibody, Inositoltrisphosphohydrolase antibody, Monophosphatidylinositol phosphodiesterase antibody, NCKAP3 antibody, Phosphatidylinositol phospholipase C antibody, Phosphoinositidase C antibody, Phosphoinositide phospholipase C antibody, Phosphoinositide phospholipase C-gamma-1 antibody, Phospholipase C 148 antibody, Phospholipase C gamma 1 antibody, Phospholipase C-gamma-1 antibody, Phospholipase C-II antibody, PLC gamma 1 antibody, PLC II antibody, PLC-148 antibody, PLC-gamma-1 antibody, PLC-II antibody, PLC1 antibody, PLC148 antibody, Plcg1 antibody, PLCG1_HUMAN antibody, PLCgamma1 antibody

UniProt: P19174

Pathways: RTK Signaling, WNT Signaling, TCR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Thyroid Hormone Synthesis, Inositol Metabolic Process, Myometrial Relaxation and Contraction, Regulation of Muscle Cell Differentiation, Regulation of G-Protein Coupled Receptor Protein Signaling, Skeletal Muscle Fiber Development, G-protein mediated Events, Signaling Events mediated by VEGFR1 and VEGFR2, Interaction of EGFR with phospholipase C-gamma, VEGFR1 Specific Signals, VEGF Signaling