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JAK3 antibody (Tyr785)

JAK3 Reactivity: Human WB, ELISA, IHC Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN7180037
  • Target See all JAK3 Antibodies
    JAK3 (Janus Kinase 3 (JAK3))
    Binding Specificity
    • 16
    • 8
    • 8
    • 8
    • 7
    • 6
    • 5
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Tyr785
    Reactivity
    • 83
    • 49
    • 19
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    Human
    Host
    • 79
    • 6
    Rabbit
    Clonality
    • 70
    • 15
    Polyclonal
    Conjugate
    • 31
    • 8
    • 5
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This JAK3 antibody is un-conjugated
    Application
    • 49
    • 29
    • 17
    • 14
    • 14
    • 11
    • 9
    • 8
    • 6
    • 3
    • 3
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
    Cross-Reactivity
    Human, Mouse, Rat
    Purification
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
    Immunogen
    Synthesized non-phosphopeptide derived from Human JAK3 around the phosphorylation site of tyrosine 785 (S-D-Y(p)-E-L).
    Isotype
    IgG
    Top Product
    Discover our top product JAK3 Primary Antibody
  • Application Notes
    WB:1:500-1:3000, IHC:1:50-1:100,
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C,-80 °C
    Storage Comment
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Target
    JAK3 (Janus Kinase 3 (JAK3))
    Alternative Name
    JAK3 (JAK3 Products)
    Synonyms
    JAK-3 antibody, JAK3_HUMAN antibody, JAKL antibody, L-JAK antibody, LJAK antibody, fae antibody, wil antibody, RATJAK3 antibody, JAK antibody, Janus kinase 3 antibody, JAK3 antibody, Jak3 antibody
    Background

    Background: Non-receptor tyrosine kinase involved in various processes such as cell growth, development, or differentiation. Mediates essential signaling events in both innate and adaptive immunity and plays a crucial role in hematopoiesis during T-cells development. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors sharing the common subunit gamma such as IL2R, IL4R, IL7R, IL9R, IL15R and IL21R. Following ligand binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins. Subsequently, phosphorylates the STATs proteins once they are recruited to the receptor. Phosphorylated STATs then form homodimer or heterodimers and translocate to the nucleus to activate gene transcription. For example, upon IL2R activation by IL2, JAK1 and JAK3 Molecules bind to IL2R beta (IL2RB) and gamma chain (IL2RG) subunits inducing the tyrosine phosphorylation of both receptor subunits on their cytoplasmic domain. Then, STAT5A AND STAT5B are recruited, phosphorylated and activated by JAK1 and JAK3. Once activated, dimerized STAT5 translocates to the nucleus and promotes the transcription of specific target genes in a cytokine-specific fashion.

    Kawamura M., Proc. Natl. Acad. Sci. U.S.A. 91:6374-6378(1994).
    Lai K.S., J. Biol. Chem. 270:25028-25036(1995).
    Grimwood J., Nature 428:529-535(2004).

    Aliases: EC 2.7.10.2 antibody, JAK 3 antibody, JAK L antibody, JAK-3 antibody, Jak3 antibody, JAK3 HUMAN antibody, JAK3_HUMAN antibody, JAKL antibody, Janus kinase 3 (a protein tyrosine kinase, leukocyte) antibody, Janus kinase 3 antibody, Janus Kinase3 antibody, L JAK antibody, L-JAK antibody, Leukocyte janus kinase antibody, LJAK antibody, Protein tyrosine kinase leukocyte antibody, Tyrosine protein kinase JAK3 antibody, Tyrosine-protein kinase JAK3 antibody

    UniProt
    P52333
    Pathways
    JAK-STAT Signaling, RTK Signaling, Response to Growth Hormone Stimulus, Regulation of Leukocyte Mediated Immunity, Production of Molecular Mediator of Immune Response, Protein targeting to Nucleus, Activated T Cell Proliferation, Unfolded Protein Response
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