ILK antibody (Ser246)
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- Target See all ILK Antibodies
- ILK (Integrin-Linked Kinase (ILK))
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Binding Specificity
- Ser246
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This ILK antibody is un-conjugated
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Application
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
- Cross-Reactivity
- Human, Mouse
- Purification
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- Immunogen
- Synthesized non-phosphopeptide derived from Human ILK around the phosphorylation site of serine 246 (I-F-S(p)-H-P).
- Isotype
- IgG
- Top Product
- Discover our top product ILK Primary Antibody
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- Application Notes
- WB:1:500-1:3000, IHC:1:50-1:100,
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C,-80 °C
- Storage Comment
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- Target
- ILK (Integrin-Linked Kinase (ILK))
- Alternative Name
- ILK (ILK Products)
- Synonyms
- CG10504 antibody, CT29478 antibody, DmILK antibody, Dmel\\CG10504 antibody, ILK antibody, ilk antibody, l(3)78Ca antibody, p59 antibody, AA511515 antibody, ESTM24 antibody, zgc:65842 antibody, ILK-1 antibody, ILK-2 antibody, P59 antibody, p59ILK antibody, Integrin linked kinase antibody, integrin linked kinase antibody, integrin linked kinase S homeolog antibody, integrin-linked protein kinase antibody, integrin-linked kinase antibody, Ilk antibody, ILK antibody, ilk.S antibody, CpipJ_CPIJ016644 antibody, Bm1_20815 antibody, Tsp_07213 antibody, Tsp_07224 antibody, Tsp_15354 antibody, ilk antibody
- Background
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Background: Receptor-proximal protein kinase regulating integrin-mediated signal transduction. May act as a mediator of inside-out integrin signaling. Focal adhesion protein part of the complex ILK-PINCH. This complex is considered to be one of the convergence points of integrin- and growth factor-signaling pathway. Could be implicated in mediating cell architecture, adhesion to integrin substrates and anchorage-dependent growth in epithelial cells. Phosphorylates beta-1 and beta-3 integrin subunit on serine and threonine residues, but also AKT1 and GSK3B.
Hannigan G.E.,Nature 379:91-96(1996).
Janji B.,Oncogene 19:3069-3077(2000).
Tadic B.,Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases.Aliases: 59 kDa serine/threonine protein kinase antibody, 59 kDa serine/threonine-protein kinase antibody, DKFZp686F1765 antibody, Epididymis secretory protein Li 28 antibody, HEL S 28 antibody, ILK 1 antibody, ILK 2 antibody, ILK antibody, ILK-1 antibody, ILK-2 antibody, ILK_HUMAN antibody, ILK1 antibody, ILK2 antibody, Integrin linked kinase 2 antibody, Integrin linked Kinase antibody, Integrin linked protein kinase antibody, Integrin-linked protein kinase antibody, p59 antibody, p59ILK antibody
- UniProt
- Q13418
- Pathways
- Regulation of Muscle Cell Differentiation, Regulation of Cell Size, Maintenance of Protein Location, Skeletal Muscle Fiber Development, Smooth Muscle Cell Migration
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