Cyclin C antibody (Ser275)

Catalog No. ABIN7179998

Product Details anti-Cyclin C Antibody

Target: Cyclin C (CCNC)

Binding Specificity: Ser275

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Cyclin C antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Cross-Reactivity: Human, Mouse

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized non-phosphopeptide derived from Human Cyclin C around the phosphorylation site of serine 275 (N-G-S(p)-Q-N).

Isotype: IgG

Application Details

Application Notes: WB:1:500-1:3000,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for Cyclin C

Target: Cyclin C (CCNC)

Alternative Name: CCNC (CCNC Products)

Synonyms: CG1C_DROME antibody, CG7281 antibody, CYCC antibody, Cln3 antibody, Cyc-C antibody, DmcycC antibody, Dmel\\CG7281 antibody, SRB11 antibody, cycC antibody, cyclinC antibody, dTRAP33 antibody, fj11d06 antibody, wu:fj11d06 antibody, zgc:73078 antibody, Cyclin-C antibody, CycC antibody, AI451004 antibody, AU020987 antibody, CG1C antibody, Cyclin C antibody, cyclin C antibody, cyclin C L homeolog antibody, cyclin-C antibody, CycC antibody, ccnc antibody, CCNC antibody, Ccnc antibody, ccnc.L antibody, LOC5577815 antibody

Background:

Background: Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Binds to and activates cyclin-dependent kinase CDK8 that phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex.

Lew D.J., Cell 66:1197-1206(1991).
Li H., Genomics 32:253-259(1996).
Mungall A.J., Nature 425:805-811(2003).

Aliases: ccnc antibody, CCNC_HUMAN antibody, CycC antibody, Cyclin C antibody, Cyclin-C antibody, hSRB11 antibody, OTTHUMP00000016897 antibody, SRB11 homolog antibody

UniProt: P24863

Pathways: Cell Division Cycle, Regulation of Lipid Metabolism by PPARalpha