Streptococcal Pyrogenic Exotoxin B (SPEB) (AA 146-398) antibody (HRP)

Catalog No. ABIN7179508

Product Details

Target: Streptococcal Pyrogenic Exotoxin B (SPEB)

Binding Specificity: AA 146-398

Reactivity: Streptococcus pyogenes

Host: Rabbit

Clonality: Polyclonal

Conjugate: HRP

Application: ELISA

Cross-Reactivity: Streptococcus pyogenes

Purification: >95%, Protein G purified

Immunogen: Recombinant Streptococcus pyogenes serotype M28 Streptopain protein (146-398AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details

Target: Streptococcal Pyrogenic Exotoxin B (SPEB)

Alternative Name: speB (SPEB Products)

Synonyms: streptococcal pyrogenic exotoxin B antibody, speB antibody

Background:

Background: Important streptococcal virulence factor which cleaves human fibronectin and degrades vitronectin. Also cleaves human IL1B precursor to form biologically active IL1B. Can induce apoptosis in human monocytes and epithelial cells in vitro, and reduces phagocytic activity in monocytic cells. Thus, may play a role in bacterial colonization, invasion, and inhibition of wound healing (By similarity).

Aliases: speB antibody, M28_Spy1721 antibody, Streptopain antibody, EC 3.4.22.10 antibody, Exotoxin type B antibody, SPE B antibody, Streptococcal cysteine proteinase antibody, Streptococcus peptidase A antibody, SPP antibody

UniProt: Q48R29