SRI antibody (AA 32-116) (HRP)

Catalog No. ABIN7179482

Product Details anti-SRI Antibody (HRP)

Target: SRI (Sorcin (SRI))

Binding Specificity: AA 32-116

Reactivity: Staphylococcus aureus

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SRI antibody is conjugated to HRP

Application: ELISA

Cross-Reactivity: Staphylococcus aureus

Purification: >95%, Protein G purified

Immunogen: Recombinant Staphylococcus aureus Staphylococcal complement inhibitor protein (32-116AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for SRI

Target: SRI (Sorcin (SRI))

Alternative Name: scn (SRI Products)

Background:

Background: Involved in countering the first line of host defense mechanisms. Efficiently inhibits opsonization, phagocytosis and killing of S.aureus by human neutrophils. Acts by binding and stabilizing human C3 convertases (C4b2a and C3bBb), leading to their inactivation. The convertases are no longer able to cleave complement C3, therefore preventing further C3b deposition on the bacterial surface and phagocytosis of the bacterium. Also prevents C5a-induced neutrophil responses.

Aliases: scn antibody, SA1754 antibody, Staphylococcal complement inhibitor antibody, SCIN antibody

UniProt: Q99SU9

Pathways: Transition Metal Ion Homeostasis, Maintenance of Protein Location, Negative Regulation of Transporter Activity