SRI antibody (AA 32-116)

Catalog No. ABIN7179479

Product Details anti-SRI Antibody

Target: SRI (Sorcin (SRI))

Binding Specificity: AA 32-116

Reactivity: Staphylococcus aureus

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SRI antibody is un-conjugated

Application: ELISA

Cross-Reactivity: Staphylococcus aureus

Purification: >95%, Protein G purified

Immunogen: Recombinant Staphylococcus aureus Staphylococcal complement inhibitor protein (32-116AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for SRI

Target: SRI (Sorcin (SRI))

Alternative Name: scn (SRI Products)

Synonyms: zgc:64070 antibody, sri antibody, SRI antibody, CP-22 antibody, CP22 antibody, SCN antibody, V19 antibody, 2210417O06Rik antibody, 2900070H08Rik antibody, Sor antibody, sorcin antibody, Sorcin antibody, sorcin L homeolog antibody, sorcin S homeolog antibody, SRI antibody, sri antibody, EDI_060410 antibody, EDI_160670 antibody, EDI_002860 antibody, EDI_076560 antibody, CpipJ_CPIJ004933 antibody, CpipJ_CPIJ008581 antibody, Tsp_05707 antibody, sri.L antibody, sri.S antibody, Sri antibody

Background:

Background: Involved in countering the first line of host defense mechanisms. Efficiently inhibits opsonization, phagocytosis and killing of S.aureus by human neutrophils. Acts by binding and stabilizing human C3 convertases (C4b2a and C3bBb), leading to their inactivation. The convertases are no longer able to cleave complement C3, therefore preventing further C3b deposition on the bacterial surface and phagocytosis of the bacterium. Also prevents C5a-induced neutrophil responses.

Aliases: scn antibody, SA1754 antibody, Staphylococcal complement inhibitor antibody, SCIN antibody

UniProt: Q99SU9

Pathways: Transition Metal Ion Homeostasis, Maintenance of Protein Location, Negative Regulation of Transporter Activity