Vpx Protein (VPX) (AA 1-112) antibody (FITC)
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- Target See all Vpx Protein (VPX) Antibodies
- Vpx Protein (VPX)
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Binding Specificity
- AA 1-112
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Reactivity
- Simian Immunodeficiency Virus (SIV)
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- FITC
- Application
- Please inquire
- Cross-Reactivity
- Simian Immunodeficiency Virus (SIV)
- Purification
- >95%, Protein G purified
- Immunogen
- Recombinant Simian immunodeficiency virus Protein Vpx protein (1-112AA)
- Isotype
- IgG
- Top Product
- Discover our top product VPX Primary Antibody
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anti-Vpx Protein (VPX) (AA 1-112), (subtype A) antibody
VPX Reactivity: Human Immunodeficiency Virus (HIV) ELISA, WB Host: Rabbit Polyclonal unconjugated
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- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4 - Preservative
- ProClin
- Precaution of Use
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C,-80 °C
- Storage Comment
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- Target
- Vpx Protein (VPX)
- Alternative Name
- vpx (VPX Products)
- Synonyms
- vpx protein antibody, vpx antibody
- Target Type
- Viral Protein
- Background
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Background: Plays a role in nuclear translocation of the viral pre-integration complex (PIC), thus is required for the virus to infect non-dividing cells. Targets specific host proteins for degradation by the 26S proteasome. Acts by associating with the cellular CUL4A-DDB1 E3 ligase complex through direct interaction with host VPRPB/DCAF-1. This change in the E3 ligase substrate specificity results in the degradation of host SAMHD1. In turn, SAMHD1 depletion allows viral replication in host myeloid cells by preventing SAMHD1-mediated hydrolysis of intracellular dNTPs necessary for reverse transcription.
Aliases: vpx antibody, Protein Vpx antibody, Viral protein X antibody, X ORF protein antibody
- UniProt
- P11266
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