Vpx Protein (VPX) (AA 1-112) antibody (Biotin)

Catalog No. ABIN7179348

Product Details

Target: Vpx Protein (VPX)

Binding Specificity: AA 1-112

Reactivity: Simian Immunodeficiency Virus (SIV)

Host: Rabbit

Clonality: Polyclonal

Conjugate: Biotin

Application: ELISA

Cross-Reactivity: Simian Immunodeficiency Virus (SIV)

Purification: >95%, Protein G purified

Immunogen: Recombinant Simian immunodeficiency virus Protein Vpx protein (1-112AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details

Target: Vpx Protein (VPX)

Alternative Name: vpx (VPX Products)

Synonyms: vpx protein antibody, vpx antibody

Target Type: Viral Protein

Background:

Background: Plays a role in nuclear translocation of the viral pre-integration complex (PIC), thus is required for the virus to infect non-dividing cells. Targets specific host proteins for degradation by the 26S proteasome. Acts by associating with the cellular CUL4A-DDB1 E3 ligase complex through direct interaction with host VPRPB/DCAF-1. This change in the E3 ligase substrate specificity results in the degradation of host SAMHD1. In turn, SAMHD1 depletion allows viral replication in host myeloid cells by preventing SAMHD1-mediated hydrolysis of intracellular dNTPs necessary for reverse transcription.

Aliases: vpx antibody, Protein Vpx antibody, Viral protein X antibody, X ORF protein antibody

UniProt: P11266