Sortilin 1 antibody (AA 610-754) (Biotin)

Catalog No. ABIN7179078

Product Details anti-Sortilin 1 Antibody (Biotin)

Target: Sortilin 1 (SORT1)

Binding Specificity: AA 610-754

Reactivity: Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Sortilin 1 antibody is conjugated to Biotin

Application: ELISA

Cross-Reactivity: Rat

Purification: >95%, Protein G purified

Immunogen: Recombinant Rat Sortilin protein (610-754AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for Sortilin 1

Target: Sortilin 1 (SORT1)

Alternative Name: Sort1 (SORT1 Products)

Background:

Background: Functions as a sorting receptor in the Golgi compartment and as a clearance receptor on the cell surface. Required for protein transport from the Golgi apparatus to the lysosomes by a pathway that is independent of the mannose-6-phosphate receptor (M6PR). Also required for protein transport from the Golgi apparatus to the endosomes. Promotes neuronal apoptosis by mediating endocytosis of the proapoptotic precursor forms of BDNF (proBDNF) and NGFB (proNGFB). Also acts as a receptor for neurotensin. May promote mineralization of the extracellular matrix during osteogenic differentiation by scavenging extracellular LPL. Probably required in adipocytes for the formation of specialized storage vesicles containing the glucose transporter SLC2A4/GLUT4 (GLUT4 storage vesicles, or GSVs). These vesicles provide a stable pool of SLC2A4 and confer increased responsiveness to insulin. May also mediate transport from the endoplasmic reticulum to the Golgi.

Aliases: Sort1 antibody, Sortilin antibody, Glycoprotein 110 antibody, Gp110 antibody, Neurotensin receptor 3 antibody, NTR3 antibody

UniProt: O54861

Pathways: Neurotrophin Signaling Pathway