IL-7 antibody

Catalog No. ABIN7178671

Product Details anti-IL-7 Antibody

Target: IL-7 (IL7) (Interleukin 7 (IL7))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IL-7 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Cross-Reactivity: Human, Mouse, Rat

Purification: Affinity purification

Immunogen: Recombinant protein of Human IL7

Isotype: IgG

Application Details

Application Notes: WB:1:500-1:2000, IHC:1:50-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Store at -20 °C or -80 °C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for IL-7

Target: IL-7 (IL7) (Interleukin 7 (IL7))

Alternative Name: IL7 (IL7 Products)

Synonyms: IL7 antibody, IL-7 antibody, A630026I06Rik antibody, Il-7 antibody, hlb368 antibody, interleukin 7 antibody, IL7 antibody, Il7 antibody

Background:

Background: IL-7 plays a key role in lymphopoiesis and lymphoid homeostasis. Stromal and epithelial cells within the bone marrow and thymus produce IL-7. The primary targets of IL-7 are T cells, B cells, and dendritic cells. IL-7 is crucial for T cell development, the importance of which is underscored by the lack of T cells in both mice and humans that are deficient in IL-7/IL-7R signaling. While IL-7 appears to be required for B cell development in mice, the role of IL-7 in human B cell development is unclear. In addition to its effects on T cell lymphopoiesis, IL-7 promotes the maintenance and survival of naïve and memory αβ T cells, as well as γδ T cells. The IL-7 receptor is a heterodimer of the common γ chain, γc, and the IL-7-specific IL-7Rα. IL-7 activates PI3K/Akt, Jak1/2, and Stat1, 3, and 5.

Aliases: IL 7 antibody; IL-7 antibody; Il7 antibody; IL7_HUMAN antibody; Interleukin 7 antibody; Interleukin-7 antibody; LP-1 antibody; Lymphopoietin 1 antibody

UniProt: P13232

Pathways: JAK-STAT Signaling