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EGLN3 antibody (AA 2-239)

EGLN3 Reactivity: Mouse ELISA, WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN7177165
  • Target See all EGLN3 Antibodies
    EGLN3 (Egl-9 Family Hypoxia Inducible Factor 3 (EGLN3))
    Binding Specificity
    • 9
    • 6
    • 6
    • 4
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    AA 2-239
    Reactivity
    • 42
    • 15
    • 9
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Mouse
    Host
    • 42
    • 4
    • 1
    Rabbit
    Clonality
    • 45
    • 2
    Polyclonal
    Conjugate
    • 28
    • 4
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This EGLN3 antibody is un-conjugated
    Application
    • 33
    • 23
    • 20
    • 6
    • 6
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    ELISA, Western Blotting (WB)
    Cross-Reactivity
    Mouse, Rat
    Purification
    >95%, Protein G purified
    Immunogen
    Recombinant Mouse Egl nine homolog 3 protein (2-239AA)
    Isotype
    IgG
    Top Product
    Discover our top product EGLN3 Primary Antibody
  • Application Notes
    Recommended dilution: WB:1:500-1:5000,
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Preservative: 0.03 % Proclin 300
    Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C,-80 °C
    Storage Comment
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Target
    EGLN3 (Egl-9 Family Hypoxia Inducible Factor 3 (EGLN3))
    Alternative Name
    Egln3 (EGLN3 Products)
    Synonyms
    zgc:77019 antibody, wu:fj78a08 antibody, EGLN3 antibody, phd3 antibody, PHD-3 antibody, PHD3 antibody, SM-20 antibody, 2610021G09Rik antibody, AI505553 antibody, AI648162 antibody, Hif-p4h-3 antibody, Phd3 antibody, HIFP4H3 antibody, HIFPH3 antibody, egl-9 family hypoxia-inducible factor 3 antibody, egl-9 family hypoxia inducible factor 3 antibody, egl-9 family hypoxia-inducible factor 3 L homeolog antibody, egln3 antibody, EGLN3 antibody, egln3.L antibody, Egln3 antibody
    Background

    Background: Cellular oxygen sensor that catalyzes, under normoxic conditions, the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates a specific proline found in each of the oxygen-dependent degradation (ODD) domains (N-terminal, NODD, and C-terminal, CODD) of HIF1A. Also hydroxylates HIF2A. Has a preference for the CODD site for both HIF1A and HIF2A. Hydroxylation on the NODD site by EGLN3 appears to require prior hydroxylation on the CODD site. Hydroxylated HIFs are then targeted for proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Under hypoxic conditions, the hydroxylation reaction is attenuated allowing HIFs to escape degradation resulting in their translocation to the nucleus, heterodimerization with HIF1B, and increased expression of hypoxy-inducible genes. ELGN3 is the most important isozyme in limiting physiological activation of HIFs (particularly HIF2A) in hypoxia. Also hydroxylates PKM in hypoxia, limiting glycolysis. Under normoxia, hydroxylates and regulates the stability of ADRB2. Regulator of cardiomyocyte and neuronal apoptosis. In cardiomyocytes, inhibits the anti-apoptotic effect of BCL2 by disrupting the BAX-BCL2 complex. In neurons, has a NGF-induced proapoptotic effect, probably through regulating CASP3 activity. Also essential for hypoxic regulation of neutrophilic inflammation.

    Aliases: Egln3Egl nine homolog 3 antibody, EC 1.14.11.29 antibody, Hypoxia-inducible factor prolyl hydroxylase 3 antibody, HIF-PH3 antibody, HIF-prolyl hydroxylase 3 antibody, HPH-3 antibody, Prolyl hydroxylase domain-containing protein 3 antibody, PHD3 antibody, SM-20 antibody

    UniProt
    Q91UZ4
    Pathways
    Positive Regulation of Endopeptidase Activity
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