TRIM27 antibody (AA 214-513)

Catalog No. ABIN7176599

Product Details anti-TRIM27 Antibody

Target: TRIM27 (Tripartite Motif Containing 27 (TRIM27))

Binding Specificity: AA 214-513

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TRIM27 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Cross-Reactivity: Human

Purification: Antigen Affinity Purified

Immunogen: Recombinant Human Zinc finger protein RFP protein (214-513AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: WB:1:500-1:2000, IHC:1:20-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for TRIM27

Target: TRIM27 (Tripartite Motif Containing 27 (TRIM27))

Alternative Name: TRIM27 (TRIM27 Products)

Background:

Background: E3 ubiquitin-protein ligase that mediates ubiquitination of PIK3C2B and inhibits its activity, mediates the formation of \\\'Lys-48\\\'-linked polyubiquitin chains, the function inhibits CD4 T-cell activation. Acts as a regulator of retrograde transport: together with MAGEL2, mediates the formation of \\\'Lys-63\\\'-linked polyubiquitin chains at \\\'Lys-220\\\' of WASH1, leading to promote endosomal F-actin assembly (PubMed:23452853). Has a transcriptional repressor activity by cooperating with EPC1. Induces apoptosis by activating Jun N-terminal kinase and p38 kinase and also increases caspase-3-like activity independently of mitochondrial events. May function in male germ cell development. Has DNA-binding activity and preferentially bound to double-stranded DNA.

Aliases: AW538890 antibody, DAAP-182E11.3 antibody, MGC189472 antibody, OTTHUMP00000029314 antibody, Ret finger protein antibody, RFP antibody, RFP transforming protein antibody, Rfp1 antibody, RING finger protein 76 antibody, RNF76 antibody, TRI27_HUMAN antibody, TRIM 27 antibody, Trim27 antibody, Tripartite motif containing 27 antibody, Tripartite motif containing protein 27 antibody, Tripartite motif protein TRIM27 antibody, Tripartite motif-containing protein 27 antibody, Zinc finger protein RFP antibody

UniProt: P14373