YTHDC1 antibody (AA 89-153) (Biotin)

Catalog No. ABIN7175951

Product Details anti-YTHDC1 Antibody (Biotin)

Target: YTHDC1 (YTH Domain Containing 1 (YTHDC1))

Binding Specificity: AA 89-153

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This YTHDC1 antibody is conjugated to Biotin

Application: ELISA

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human YTH domain-containing protein 1 protein (89-153AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for YTHDC1

Target: YTHDC1 (YTH Domain Containing 1 (YTHDC1))

Alternative Name: YTHDC1 (YTHDC1 Products)

Synonyms: C80342 antibody, mKIAA1966 antibody, A730098D12Rik antibody, zgc:101592 antibody, MGC89461 antibody, MGC137509 antibody, DKFZp459L1228 antibody, YT521 antibody, YT521-B antibody, Yt521 antibody, YTH domain containing 1 antibody, YTH domain containing 1 L homeolog antibody, Ythdc1 antibody, YTHDC1 antibody, ythdc1 antibody, ythdc1.L antibody

Background:

Background: Regulator of alternative splicing that specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs (PubMed:26318451, PubMed:26876937, PubMed:25242552). M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in the efficiency of mRNA splicing, processing and stability (PubMed:26318451, PubMed:25242552). Acts as a key regulator of exon-inclusion or exon-skipping during alternative splicing via interaction with mRNA splicing factors SRSF3 and SRSF10 (PubMed:26876937). Specifically binds m6A-containing mRNAs and promotes recruitment of SRSF3 to its mRNA-binding elements adjacent to m6A sites, leading to exon-inclusion during alternative splicing (PubMed:26876937). In contrast, interaction with SRSF3 prevents interaction with SRSF10, a splicing factor that promotes exon skipping: this prevents SRSF10 from binding to its mRNA-binding sites close to m6A-containing regions, leading to inhibit exon skipping during alternative splicing (PubMed:26876937). May also regulate alternative splice site selection (PubMed:20167602).

Aliases: YTHDC1 antibody, KIAA1966 antibody, YT521 antibody, YTH domain-containing protein 1 antibody, Splicing factor YT521 antibody, YT521-B antibody

UniProt: Q96MU7