WDR41 antibody (AA 7-284)

Catalog No. ABIN7175751

Product Details anti-WDR41 Antibody

Target: WDR41 (WD Repeat Domain 41 (WDR41))

Binding Specificity: AA 7-284

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This WDR41 antibody is un-conjugated

Application: ELISA, Immunofluorescence (IF)

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human WD repeat-containing protein 41 protein (7-284AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IF:1:50-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for WDR41

Target: WDR41 (WD Repeat Domain 41 (WDR41))

Alternative Name: WDR41 (WDR41 Products)

Synonyms: WDR41 antibody, MGC142930 antibody, wdr41 antibody, fj48d04 antibody, wu:fj48d04 antibody, zgc:110041 antibody, B830029I03Rik antibody, MSTP048 antibody, WD repeat domain 41 antibody, Wdr41 antibody, WDR41 antibody, wdr41 antibody

Background:

Background: Non-catalytic component of the C9orf72-SMCR8 complex, a complex that has guanine nucleotide exchange factor (GEF) activity and regulates autophagy (PubMed:27193190, PubMed:27103069, PubMed:27617292, PubMed:28195531). The C9orf72-SMCR8 complex promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB8A and RAB39B into their active GTP-bound form, thereby promoting autophagosome maturation (PubMed:27103069). The C9orf72-SMCR8 complex also acts as a negative regulator of autophagy initiation by interacting with the ATG1/ULK1 kinase complex and inhibiting its protein kinase activity (PubMed:27103069, PubMed:27617292).

Aliases: FLJ10904 antibody, MSTP048 antibody, WD repeat domain 41 antibody, WD repeat protein 41 antibody, WD repeat-containing protein 41 antibody, WDR 41 antibody, WDR41 antibody, WDR41_HUMAN antibody

UniProt: Q9HAD4