HSD17B12 antibody (AA 40-181) (Biotin)

Catalog No. ABIN7175450

Product Details anti-HSD17B12 Antibody (Biotin)

Target: HSD17B12 (Hydroxysteroid (17-Beta) Dehydrogenase 12 (HSD17B12))

Binding Specificity: AA 40-181

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HSD17B12 antibody is conjugated to Biotin

Application: ELISA

Cross-Reactivity: Human

Purification: Antigen Affinity Purified

Immunogen: Recombinant Human Very-long-chain 3-oxoacyl-CoA reductase protein (40-181AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for HSD17B12

Target: HSD17B12 (Hydroxysteroid (17-Beta) Dehydrogenase 12 (HSD17B12))

Alternative Name: HSD17B12 (HSD17B12 Products)

Synonyms: KAR antibody, SDR12C1 antibody, 2610510O05Rik antibody, AI172963 antibody, KIK-I antibody, Kik1 antibody, HSD17B12 antibody, kar antibody, sdr12c1 antibody, 17-beta-HSD 12-A antibody, fi06g11 antibody, wu:fi06g11 antibody, zf3.1 antibody, zfHSD17B12A antibody, zgc:55589 antibody, zgc:77599 antibody, hydroxysteroid 17-beta dehydrogenase 12 antibody, hydroxysteroid (17-beta) dehydrogenase 12 antibody, hydroxysteroid (17-beta) dehydrogenase 12 L homeolog antibody, hydroxysteroid (17-beta) dehydrogenase 12a antibody, HSD17B12 antibody, Hsd17b12 antibody, hsd17b12.L antibody, hsd17b12a antibody

Background:

Background: Catalyzes the second of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme has a 3-ketoacyl-CoA reductase activity, reducing 3-ketoacyl-CoA to 3-hydroxyacyl-CoA, within each cycle of fatty acid elongation. Thereby, it may participate to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. May also catalyze the transformation of estrone (E1) into estradiol (E2) and play a role in estrogen formation.

Aliases: 12,3-ketoacyl-CoA reductase,short chain antibody, 17 beta HSD 12 antibody, 17 beta hydroxysteroid dehydrogenase 12 antibody, 17-@beta-HSD XII antibody, 17-@beta-hydroxysteroid dehydrogenase XII antibody, 17-beta-HSD 12 antibody, 17-beta-hydroxysteroid dehydrogenase 12 antibody, 17beta HSD type 12 antibody, 3 ketoacyl CoA reductase antibody, 3-ketoacyl-CoA reductase antibody, DHB12_HUMAN antibody, Estradiol 17 beta dehydrogenase 12 antibody, Estradiol 17-beta-dehydrogenase 12 antibody, HSD17B12 antibody, Hydroxysteroid (17-beta) dehydrogenase 12 antibody, KAR antibody, KIK-I antibody, Kik1 antibody, SDR12C1 antibody, Short chain dehydrogenase/reductase family 12C member 1 antibody, Steroid dehydrogenase homolog antibody

UniProt: Q53GQ0

Pathways: Steroid Hormone Biosynthesis