SNF8 antibody (AA 1-258) (FITC)

Catalog No. ABIN7175342

Product Details anti-SNF8 Antibody (FITC)

Target: SNF8 (Vacuolar-sorting Protein SNF8 (SNF8))

Binding Specificity: AA 1-258

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SNF8 antibody is conjugated to FITC

Application: Please inquire

Cross-Reactivity: Human

Purification: Antigen Affinity Purified

Immunogen: Recombinant Human Vacuolar-sorting protein SNF8 protein (1-258AA)

Isotype: IgG

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for SNF8

Target: SNF8 (Vacuolar-sorting Protein SNF8 (SNF8))

Alternative Name: SNF8 (SNF8 Products)

Synonyms: d11moh34 antibody, vps22 antibody, Dot3 antibody, EAP30 antibody, VPS22 antibody, D11moh34 antibody, RGD1310144 antibody, D11Moh34 antibody, D11MOH34 antibody, zgc:101578 antibody, SNF8, ESCRT-II complex subunit antibody, eap30 subunit of ell complex, putative antibody, EAP30 subunit of ELL complex antibody, SNF8, ESCRT-II complex subunit S homeolog antibody, SNF8, ESCRT-II complex subunit, homolog (S. cerevisiae) antibody, snf8 antibody, TA17290 antibody, TVAG_107410 antibody, Bm1_05145 antibody, SNF8 antibody, Snf8 antibody, snf8.S antibody

Background:

Background: Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. The ESCRT-II complex may also play a role in transcription regulation by participating in derepression of transcription by RNA polymerase II, possibly via its interaction with ELL. Required for degradation of both endocytosed EGF and EGFR, but not for the EGFR ligand-mediated internalization. It is also required for the degradation of CXCR4. Required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413).

Aliases: Dot3 antibody, ELL associated protein of 30 kDa antibody, ELL-associated protein of 30 kDa antibody, ESCRT-II complex subunit VPS22 antibody, hVps22 antibody, snf8 antibody, SNF8 ESCRTII complex subunit homolog (S cerevisiae) antibody, SNF8_HUMAN antibody, Vacuolar sorting protein SNF8 antibody, Vacuolar-sorting protein SNF8 antibody, VPS22 antibody

UniProt: Q96H20