VPS11 antibody (AA 692-941)

Catalog No. ABIN7175282

Product Details anti-VPS11 Antibody

Target: VPS11 (Vacuolar Protein Sorting 11 Homolog (VPS11))

Binding Specificity: AA 692-941

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This VPS11 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC)

Cross-Reactivity: Human

Purification: Antigen Affinity Purified

Immunogen: Recombinant Human Vacuolar protein sorting-associated protein 11 homolog protein (692-941AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:20-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for VPS11

Target: VPS11 (Vacuolar Protein Sorting 11 Homolog (VPS11))

Alternative Name: VPS11 (VPS11 Products)

Synonyms: zgc:112329 antibody, ATVPS11 antibody, F5G3.7 antibody, F5G3_7 antibody, vacuolar protein sorting 11 antibody, DDBDRAFT_0204454 antibody, DDBDRAFT_0234135 antibody, DDB_0204454 antibody, DDB_0234135 antibody, end1 antibody, pep5 antibody, hvps11 antibody, rnf108 antibody, 1200011A11Rik antibody, END1 antibody, PEP5 antibody, RNF108 antibody, hVPS11 antibody, VPS11, CORVET/HOPS core subunit antibody, vacuolar protein sorting 11 antibody, vacuolar protein sorting protein 11 antibody, VPS11, CORVET/HOPS core subunit S homeolog antibody, Vacuolar peripheral membrane protein similar to S. cerevisiae PEP5 (YMR231W); C terminus is almost identical to nonallelic CaP19.1278 antibody, 7-fold repeat in clathrin and VPS proteins repeat-containing protein antibody, vacuolar protein sorting-associated protein 11 homolog antibody, VPS11 CORVET/HOPS core subunit antibody, VPS11 antibody, vps11 antibody, MCYG_02909 antibody, vps11.S antibody, LOC100632536 antibody, Vps11 antibody

Background:

Background: Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations (PubMed:11382755, PubMed:23351085, PubMed:24554770, PubMed:25266290, PubMed:25783203). Required for fusion of endosomes and autophagosomes with lysosomes (PubMed:25783203). Involved in cargo transport from early to late endosomes and required for the transition from early to late endosomes (PubMed:21148287). Involved in the retrograde Shiga toxin transport (PubMed:23593995).

Aliases: END1 antibody, HGNC:14583 antibody, hVPS11 antibody, PEP5 antibody, PP3476 antibody, RING finger protein 108 antibody, RNF108 antibody, Vacuolar protein sorting 11 (yeast homolog) antibody, Vacuolar protein sorting 11 (yeast) antibody, Vacuolar protein sorting 11 homolog (S. cerevisiae) antibody, Vacuolar protein sorting 11 homolog antibody, Vacuolar protein sorting associated protein 11 homolog antibody, Vacuolar protein sorting protein 11 antibody, Vacuolar protein sorting-associated protein 11 homolog antibody, vps11 antibody, VPS11_HUMAN antibody

UniProt: Q9H270

Pathways: SARS-CoV-2 Protein Interactome