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UVSSA/KIAA1530 antibody (AA 143-206)

UVSSA Reactivity: Human ELISA, IHC Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN7175182
  • Target See all UVSSA/KIAA1530 (UVSSA) Antibodies
    UVSSA/KIAA1530 (UVSSA) (UV Stimulated Scaffold Protein A (UVSSA))
    Binding Specificity
    • 3
    • 2
    • 1
    • 1
    AA 143-206
    Reactivity
    Human
    Host
    • 5
    • 2
    Rabbit
    Clonality
    • 6
    • 1
    Polyclonal
    Conjugate
    • 4
    • 1
    • 1
    • 1
    This UVSSA/KIAA1530 antibody is un-conjugated
    Application
    • 4
    • 2
    • 2
    • 2
    ELISA, Immunohistochemistry (IHC)
    Cross-Reactivity
    Human
    Purification
    >95%, Protein G purified
    Immunogen
    Recombinant Human UV-stimulated scaffold protein A protein (143-206AA)
    Isotype
    IgG
    Top Product
    Discover our top product UVSSA Primary Antibody
  • Application Notes
    Recommended dilution: IHC:1:200-1:500,
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Preservative: 0.03 % Proclin 300
    Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C,-80 °C
    Storage Comment
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Target
    UVSSA/KIAA1530 (UVSSA) (UV Stimulated Scaffold Protein A (UVSSA))
    Alternative Name
    UVSSA (UVSSA Products)
    Synonyms
    KIAA1530 antibody, UVSS3 antibody, kiaa1530 antibody, 4933407H18Rik antibody, D330017J19Rik antibody, Kiaa1530 antibody, mKIAA1530 antibody, UV stimulated scaffold protein A antibody, UVSSA antibody, uvssa antibody, Uvssa antibody
    Background

    Background: Factor involved in transcription-coupled nucleotide excision repair (TC-NER) in response to UV damage. TC-NER allows RNA polymerase II-blocking lesions to be rapidly removed from the transcribed strand of active genes. Acts by promoting stabilization of ERCC6 by recruiting deubiquitinating enzyme USP7 to TC-NER complexes, preventing UV-induced degradation of ERCC6 by the proteasome. Interacts with the elongating form of RNA polymerase II (RNA pol IIo) and facilitates its ubiquitination at UV damage sites, leading to promote RNA pol IIo backtracking to allow access to the nucleotide excision repair machinery. Not involved in processing oxidative damage.

    Aliases: hypothetical protein LOC57654 antibody, K1530_HUMAN antibody, KIAA1530 antibody, Uncharacterized protein KIAA1530 antibody, UV stimulated scaffold protein A antibody, UVSS3 antibody, UVSSA antibody

    UniProt
    Q2YD98
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