UGT1A1 antibody (AA 395-482) (HRP)

Catalog No. ABIN7174626

Product Details anti-UGT1A1 Antibody (HRP)

Target: UGT1A1 (UDP Glucuronosyltransferase 1 Family, Polypeptide A1 (UGT1A1))

Binding Specificity: AA 395-482

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This UGT1A1 antibody is conjugated to HRP

Application: ELISA

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human UDP-glucuronosyltransferase 1-1 protein (395-482AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for UGT1A1

Target: UGT1A1 (UDP Glucuronosyltransferase 1 Family, Polypeptide A1 (UGT1A1))

Alternative Name: UGT1A1 (UGT1A1 Products)

Synonyms: BILIQTL1 antibody, GNT1 antibody, HUG-BR1 antibody, UDPGT antibody, UDPGT 1-1 antibody, UGT1 antibody, UGT1A antibody, Gnt1 antibody, UGT1A01 antibody, Udpgt-1a antibody, UgtBr1 antibody, Udpgt antibody, Ugt1 antibody, zgc:123097 antibody, UDP glucuronosyltransferase family 1 member A1 antibody, UDP glucuronosyltransferase 1 family, polypeptide A1 antibody, UDP-glucuronosyltransferase 1-1 antibody, UDP-glucuronosyltransferase antibody, UDP-glucuronosyltransferase 1-6 antibody, UDP glucuronosyltransferase 1 family polypeptide a1 antibody, UGT1A1 antibody, Ugt1a1 antibody, LOC100065342 antibody, LOC100125517 antibody, LOC100229734 antibody, LOC100405984 antibody, LOC100511479 antibody, ugt1a1 antibody

Background:

Background: UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform glucuronidates bilirubin IX-alpha to form both the IX-alpha-C8 and IX-alpha-C12 monoconjugates and diconjugate. Is also able to catalyze the glucuronidation of 17beta-estradiol, 17alpha-ethinylestradiol, 1-hydroxypyrene, 4-methylumbelliferone, 1-naphthol, paranitrophenol, scopoletin, and umbelliferone. Isoform 2 lacks transferase activity but acts as a negative regulator of isoform 1.

Aliases: BILIQTL1 antibody, Bilirubin specific UDPGT isozyme 1 antibody, bilirubin UDP glucuronosyltransferase 1 1 antibody, bilirubin UDP glucuronosyltransferase isozyme 1 antibody, Bilirubin-specific UDPGT isozyme 1 antibody, EC 2.4.1.17 antibody, GNT1 antibody, HUG BR1 antibody, HUG-BR1 antibody, HUGBR1 antibody, PHENOL/BILIRUBIN UDP GLUCURONOSYLTRANSFERASE antibody, UD11_HUMAN antibody, UDP glucuronosyltransferase 1 1 [Precursor] antibody, UDP glucuronosyltransferase 1 family polypeptide A1 antibody, UDP glucuronosyltransferase 1A1 antibody, UDP GLYCOSYLTRANSFERASE 1 antibody, UDP-glucuronosyltransferase 1-1 antibody, UDP-glucuronosyltransferase 1-A antibody, UDP-glucuronosyltransferase 1A1 antibody, UDPGT antibody, UDPGT 1-1 antibody, UGT 1A antibody, UGT-1A antibody, UGT1 antibody, UGT1 01 antibody, UGT1*1 antibody, UGT1-01 antibody, UGT1.1 antibody, UGT1A antibody, Ugt1a1 antibody, URIDINE DIPHOSPHATE GLUCURONOSYLTRANSFERASE, BILIRUBIN/PHENOL antibody, URIDINE DIPHOSPHATE GLYCOSYLTRANSFERASE 1 antibody, URIDINE DIPHOSPHATE GLYCOSYLTRANSFERASE 1 FAMILY, POLYPEPTIDE A1 antibody

UniProt: P22309

Pathways: Steroid Hormone Biosynthesis, Regulation of Lipid Metabolism by PPARalpha